Microwave synthesis of upconverting nanoparticles with bis(2-ethylhexyl) adipate

Egatz-Gómez, Ana; Asher, Michaela; Peterson, Rozabel; Roldán, Manuel A.; Ros, Alexandra

doi:10.1039/d2ra03262g

Cited by 3 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, both these hotplates have different temperature-cotrol logic which cannot be matched. Heating rate is known to be an important parameter in UCNP synthesis [69,70]. Indeed, a recent exemplary study on reproducible UCNP synthesis by Andresen et al identified heating rate as a key parameter [34].…”

Section: Resultsmentioning

confidence: 99%

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles

Birch

Bruckbauer

Gajewska

et al. 2023

Methods Appl. Fluoresc.

View full text Add to dashboard Cite

Polyvinylpyrrolidone (PVP) can be used to produce upconversion nanoparticles (UCNPs) in an advantageous manner, i.e. at modest temperatures in open-to-air conditions with simple hotplate and flask apparatus. However, the influence of PVP parameters on the formation of UCNPs has not been previously investigated. In this exploratory study, we establish that PVP molecular weight and relative amount of PVP can greatly influence the morphology and diameter of NaYF4:Yb,Er UCNPs produced via the PVP-assisted route. At nominal amounts of PVP, varying the molecular weight of PVP in synthesis between 10,000 g/mol (PVP10), 40,000 g/mol (PVP40), and 55,000 g/mol (PVP55), had minimal effect on UCNP morphology, whereas reducing the quantity of PVP10 and PVP40 in the reaction to 10% of the nominal amount resulted in two notable effects: (1) the generation of a greater range of UCNP diameters and (2) the production of an unexpected sub-population of rhombus-shaped UCNPs. Bulk and individual nanoparticle analysis indicates that all UCNP morphologies were cubic (α-phase) crystal structure and consisted of NaYF4:Yb,Er. Optical emission properties exhibited only modest green and red luminescence emission ratio when PVP parameters were varied. However, separately produced PVP40 NaYF4:Yb,Tm UCNPs exhibited a much more intense and dual-band blue /red emission. This exploratory work demonstrates that tailoring PVP content in synthesis of UCNPs can greatly alter morphology of UCNPs produced and should be carefully considered in experimental design. However, the underlying mechanisms of action of the role PVP plays in this synthesis remain unclear. Ultimately, significant further work is still required to fully elucidate the relevant chemistry to achieve full control of PVP-UCNP synthesis.

show abstract

Section: Resultsmentioning

confidence: 99%

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles

Birch

Bruckbauer

Gajewska

et al. 2023

Methods Appl. Fluoresc.

View full text Add to dashboard Cite

show abstract

“…A strong dependence on the size of upconversion NaYF 4 : Yb 3+ ,Er 3+ nanocrystals was observed; the larger the particles, the higher the emission (Schietinger et al, 2009), which also affects the synthesis strategy of UCNPs. Methods developed for the preparation of hexagonal-phase UCNPs with uniform size (Wang et al, 2012), which is advantageous for biomedical applications, include thermal decomposition (Xie et al, 2013), hydrothermal/solvothermal synthesis with phase transfer (Wang et al, 2009), microemulsion (Shan et al, 2011), sol-gel processing (Yao et al, 2016) and microwave synthesis (Egatz-Gomez et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

et al. 2023

View full text Add to dashboard Cite

Large (120 nm) hexagonal NaYF4:Yb, Er nanoparticles (UCNPs) were synthesized by high-temperature coprecipitation method and coated with poly(ethylene glycol)-alendronate (PEG-Ale), poly (N,N-dimethylacrylamide-co-2-aminoethylacrylamide)-alendronate (PDMA-Ale) or poly(methyl vinyl ether-co-maleic acid) (PMVEMA). The colloidal stability of polymer-coated UCNPs in water, PBS and DMEM medium was investigated by dynamic light scattering; UCNP@PMVEMA particles showed the best stability in PBS. Dissolution of the particles in water, PBS, DMEM and artificial lysosomal fluid (ALF) determined by potentiometric measurements showed that all particles were relatively chemically stable in DMEM. The UCNP@Ale-PEG and UCNP@Ale-PDMA particles were the least soluble in water and ALF, while the UCNP@PMVEMA particles were the most chemically stable in PBS. Green fluorescence of FITC-Ale-modified UCNPs was observed inside the cells, demonstrating successful internalization of particles into cells. The highest uptake was observed for neat UCNPs, followed by UCNP@Ale-PDMA and UCNP@PMVEMA. Viability of C6 cells and rat mesenchymal stem cells (rMSCs) growing in the presence of UCNPs was monitored by Alamar Blue assay. Culturing with UCNPs for 24 h did not affect cell viability. Prolonged incubation with particles for 72 h reduced cell viability to 40%–85% depending on the type of coating and nanoparticle concentration. The greatest decrease in cell viability was observed in cells cultured with neat UCNPs and UCNP@PMVEMA particles. Thanks to high upconversion luminescence, high cellular uptake and low toxicity, PDMA-coated hexagonal UCNPs may find future applications in cancer therapy.

show abstract

Impact of synthesis routes on the optical performance of upconverting and near-infrared emitting lanthanide-doped nanoparticles

Homann,

Liu,

Barbosa

et al. 2024

Including Actinides Women's Contribution to F-Element Science, Part 1

View full text Add to dashboard Cite

Microwave synthesis of upconverting nanoparticles with bis(2-ethylhexyl) adipate

Abstract: A mixture of bis(2-ethylhexyl) adipate and oleic acid provides scale-up potential and speedy heating rates in the microwave-assisted organic synthesis of upconverting nanoparticles with tunable size, crystallinity, and hydrophilic character.

Cited by 3 publications

References 77 publications

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

Impact of synthesis routes on the optical performance of upconverting and near-infrared emitting lanthanide-doped nanoparticles

Contact Info

Product

Resources

About

Microwave synthesis of upconverting nanoparticles with bis(2-ethylhexyl) adipate

Abstract: A mixture of bis(2-ethylhexyl) adipate and oleic acid provides scale-up potential and speedy heating rates in the microwave-assisted organic synthesis of upconverting nanoparticles with tunable size, crystallinity, and hydrophilic character.

Cited by 3 publications

References 77 publications

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF4:Yb,Er upconversion nanoparticles

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF4:Yb,Er upconversion nanoparticles

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

Impact of synthesis routes on the optical performance of upconverting and near-infrared emitting lanthanide-doped nanoparticles

Contact Info

Product

Resources

About

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles

Influence of polyvinylpyrrolidone (PVP) in the synthesis of luminescent NaYF₄:Yb,Er upconversion nanoparticles