Microwave synthesis of hydroxyapatite bioceramic and tribological studies of its composites with SrCO3 and ZrO2

Gautam, Chandkiram; Tamuk, M.; Manpoong, C. W.; Gautam, Satyam Shivam; Kumar, Sunil; Singh, Archana; Mishra, Vijay Kumar

doi:10.1007/s10853-016-9802-1

Cited by 28 publications

(15 citation statements)

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“…8 The unadulterated nHAp material cannot fulfill the prerequisites of the embedded bone because of its fragile nature and low mechanical properties which limit their applications. 9 Therefore, with the aim of improving the mechanical properties, the various nHAp composites have been developed to enhance the mechanical strength of the pure nHAp, such as HAp–MgO, 10 HAp–SrCO 3 , 11 HAp–La 2 O 3 , 12 HAp–Al 2 O 3 , 13 and HAp–GO. 14 Furthermore, it is also reported that the addition of Fe 2 O 3 into the nHAp considerably improves the mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Graphene Nanoplatelet-Incorporated Porous Hydroxyapatite Composites: Improved Mechanical and in Vivo Imaging Performances for Emerging Biomedical Applications

et al. 2019

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Three-dimensional nanocomposites exhibit unexpected mechanical and biological properties that are produced from two-dimensional graphene nanoplatelets and oxide materials. In the present study, various composites of microwave-synthesized nanohydroxyapatite (nHAp) and graphene nanoparticles (GNPs), (100 – x )HAp– x GNPs ( x = 0, 0.1, 0.2, 0.3, and 0.5 wt %), were successfully synthesized using a scalable bottom-up approach, that is, a solid-state reaction method. The structural, morphological and mechanical properties were studied using various characterization techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and universal testing machine (UTM). XRD studies revealed that the prepared composites have high-order crystallinity. Addition of GNPs into nHAp significantly improved the mechanical properties. Three-dimensional nanocomposite 99.5HAp–0.5GNPs exhibited exceptionally high mechanical properties, for example, a fracture toughness of ∼116 MJ/m 3 , Young’s modulus of ∼98 GPa, and compressive strength of 96.04 MPa, which were noticed to be much greater than in the pure nHAp. The MTT assay and cell imaging behaviors were carried out on the gut tissues of Drosophila third instars larvae and on primary rat osteoblast cells for the sample 99.5HAp–0.5GNPs that have achieved the highest mechanical properties. The treatment with lower concentrations of 10 μg/mL on the gut tissues of Drosophila and 1 and 5 μg/mL of this composite sample showed favorable cell viability. Therefore, owing to the excellent porous nature, interconnected surface morphology, and mechanical and biological properties, the prepared composite sample 99.5HAp–0.5GNPs stood as a promising biomaterial for bone implant applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Graphene Nanoplatelet-Incorporated Porous Hydroxyapatite Composites: Improved Mechanical and in Vivo Imaging Performances for Emerging Biomedical Applications

et al. 2019

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“…One of the most well-known modifications is the synthesis performed through microwave radiation, used to activate the reaction. Microwave heating generates heat within the samples, reducing reaction time and increasing nucleation rate and growth [95,98,[174][175][176]. HAp can be obtained with differentiated structures, such as nanostructured mesoporous microspheres [177], mesoporous lozenges [178], and hollow microspheres [45], using various organic additives, such as amino acids [179,180], surfactants [160,[180][181][182][183][184][185], or natural origin substances [186,187].…”

Section: Combination Of Methodsmentioning

confidence: 99%

“…Doping of HAp with Fe 3+ resulted in an increased negative surface charge and, consequently, increased adhesion in osteoblastic cells compared to samples doped with Mn 2+ and pure HAp. Gautam et al [174] synthesized HAp composites with SrCO 3 and ZrO 2 varying the dopant amount in 2, 4, and 6 wt%. Results showed that the presence of dopant aided grain growth during sintering processes, as well as increased wear resistance and specific wear rate.…”

Section: -mentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

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Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

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“…where D represents the average dimension of crystallites in a direction normal to the diffraction plane hkl, B stands for full width at half maximum of the peak, λ is the diffraction wavelength (0.154059 nm) and θ is the diffraction angle [23]. The Bragg reflections at five major intensity peaks are selected for calculating the crystallite size of the synthesized HAp.…”

Section: Xrd Analysismentioning

confidence: 99%

Effect of pretreatment processes on physicochemical properties of hydroxyapatite synthesized from Puntius conchonius fish scales

Deb

Deoghare

2019

Bull Mater Sci

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The current study emphasizes on the novel idea of synthesizing hydroxyapatite (HAp) from Puntius conchonius fish scales' bio-waste and study the effect of acid, alkali and acid-alkali pretreatments on its physicochemical properties. Material characterization is carried out to study the physicochemical properties of the synthesized HAp using Fouriertransform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy energy dispersive X-ray spectroscopy (SEM-EDX) and transmission electron microscopy (TEM) analysis. FTIR and XRD plots show peaks corresponding to natural bone apatite which confirms the formation of HAp. TG analysis shows a maximum weight loss of 2.28% indicating high thermal stability of HAp beyond 800 • C. SEM micrographs illustrate highly porous morphology with interconnected pores. EDX analysis of the HAp exhibits close proximity of the calcium/phosphorous (Ca/P) ratio to natural bone apatite. TEM micrographs show the formation of polycrystalline HAp particles with size ranging from 38 ± 1.54 to 219 ± 5.88 nm. A comparative study on the physicochemical properties of HAp synthesized using three different pretreatment processes is performed. Results reveal that HAp synthesized from acid-treated fish scales show highest yield percentage, better thermal stability and highly porous morphology with a particle size of 38 ± 1.54 nm. Thus, HAp synthesized from acid-treated fish scales can be a promising candidate for the development of porous bone scaffolds.

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Microwave synthesis of hydroxyapatite bioceramic and tribological studies of its composites with SrCO3 and ZrO2

Cited by 28 publications

References 29 publications

Fabrication of Graphene Nanoplatelet-Incorporated Porous Hydroxyapatite Composites: Improved Mechanical and in Vivo Imaging Performances for Emerging Biomedical Applications

Fabrication of Graphene Nanoplatelet-Incorporated Porous Hydroxyapatite Composites: Improved Mechanical and in Vivo Imaging Performances for Emerging Biomedical Applications

A brief review on hydroxyapatite production and use in biomedicine

Effect of pretreatment processes on physicochemical properties of hydroxyapatite synthesized from Puntius conchonius fish scales

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