This paper focuses on the analysis of splitter/ combiner microstrip sections where each branch is loaded with a complementary split ring resonator (CSRR). The distance between CSRRs is high, and hence their coupling can be neglected. If the structure exhibits perfect symmetry with regard to the axial plane, a single transmission zero (notch) at the fundamental resonance of the CSRR, arises. Conversely, two notches (i.e., frequency splitting) appear if symmetry is disrupted, and their positions are determined not only by the characteristics of the CSRRs but also by the length of the splitter/combiner sections. A model that includes lumped elements (accounting for the CSRR-loaded line sections) and distributed components (corresponding to the transmission lines) is proposed and used to infer the position of the transmission zeros. Frequency splitting is useful for the implementation of differential sensors and comparators based on symmetry disruption. Using the model, the length of the splitter/combiner sections necessary to optimize the sensitivity of the structures as sensing elements is determined. Parameter extraction and comparison to electromagnetic simulations and measurements in several symmetric and asymmetric structures is used to validate the model. Finally, a prototype device sensor/comparator based on the proposed CSRRloaded splitter/combiner microstrip sections is presented.