Microwave radiometric imaging (MWI) for the characterisation of breast tumours

Mouty, S.; Bocquet, B.; Ringot, R.; Rocourt, N.; Devos, Philippe

doi:10.1051/epjap:2000121

Cited by 30 publications

(12 citation statements)

References 6 publications

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“…In the 1990’s, there were approximately a dozen journal papers related to microwave breast imaging (see, for example, [1]–[4]), whereas between 2000 and the present nearly 100 journal papers have appeared (see, for example, [5] and references therein) with over a quarter of those published last year. The body of work on microwave breast cancer detection is quite diverse, and includes narrowband and wideband inverse scattering or tomographic techniques [6]–[10]; ultrawideband radar and other time-domain techniques such as time reversal [11]–[15]; microwave-induced thermoacoustic tomography [16], [17]; microwave radiometry [18]–[20]; and microwave holography [21]. There is also continuing interest in research and development of microwave therapeutic techniques for the breast, such as microwave-induced hyperthermia and microwave ablation.…”

Section: Introductionmentioning

confidence: 99%

Development of Anatomically Realistic Numerical Breast Phantoms With Accurate Dielectric Properties for Modeling Microwave Interactions With the Human Breast

Zastrow

Davis

Lazebnik

et al. 2008

IEEE Trans. Biomed. Eng.

277

226

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Computational electromagnetics models of microwave interactions with the human breast serve as an invaluable tool for exploring the feasibility of new technologies and improving design concepts related to microwave breast cancer detection and treatment. In this paper we report the development of a collection of anatomically realistic 3D numerical breast phantoms of varying shape, size, and radiographic density which can be readily used in FDTD computational electromagnetics models. The phantoms are derived from T1-weighted magnetic resonance images (MRIs) of prone patients. Each MRI is transformed into a uniform grid of dielectric properties using several steps. First, the structure of each phantom is identified by applying image processing techniques to the MRI. Next, the voxel intensities of the MRI are converted to frequency-dependent and tissue-dependent dielectric properties of normal breast tissues via a piecewise-linear map. The dielectric properties of normal breast tissue are taken from the recently completed large-scale experimental study of normal breast tissue dielectric properties conducted by the Universities of Wisconsin and Calgary. The comprehensive collection of numerical phantoms is made available to the scientific community through an online repository.

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Section: Introductionmentioning

confidence: 99%

Development of Anatomically Realistic Numerical Breast Phantoms With Accurate Dielectric Properties for Modeling Microwave Interactions With the Human Breast

Zastrow

Davis

Lazebnik

et al. 2008

IEEE Trans. Biomed. Eng.

277

226

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“…Among the most widely investigated applications are breast cancer detection [12-14], brain temperature monitoring in new born infants after hypoxia ischemia [15, 16], tissue temperature monitoring for feedback power control of superficial hyperthermia [17-19] and interstitial MW applicators [20, 21], and noninvasive thermometry for intracranial focused deep brain hyperthermia [22, 23]. MW radiometry involves collecting thermal noise power emitted by the body in the EM spectrum (typically 1–4 GHz) using an antenna.…”

Section: Introductionmentioning

confidence: 99%

Detection of Vesicoureteral Reflux Using Microwave Radiometry—System Characterization With Tissue Phantoms

Arunachalam

Maccarini

Luca

et al. 2011

IEEE Trans. Biomed. Eng.

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Microwave (MW) radiometry is proposed for passive monitoring of kidney temperature to detect vesicoureteral reflux (VUR) of urine that is externally heated by a MW hyperthermia device and thereafter reflows from the bladder to kidneys during reflux. Here we characterize in tissuemimicking phantoms the performance of a 1.375 GHz radiometry system connected to an electromagnetically (EM) shielded microstrip log spiral antenna optimized for VUR detection. Phantom EM properties are characterized using a coaxial dielectric probe and network analyzer (NA). Power reflection and receive patterns of the antenna are measured in layered tissue phantom. Receiver spectral measurements are used to assess EM shielding provided by a metal cup surrounding the antenna. Radiometer and fiberoptic temperature data are recorded for varying volumes (10-30 mL) and temperatures (40-46°C) of the urine phantom at 35 mm depth surrounded by 36.5°C muscle phantom. Directional receive pattern with about 5% power spectral density at 35 mm target depth and better than −10dB return loss from tissue load are measured for the antenna. Antenna measurements demonstrate no deterioration in power reception and effective EM shielding in the presence of the metal cup. Radiometry power measurements are in excellent agreement with the temperature of the kidney phantom. Laboratory testing of the radiometry system in temperature controlled phantoms supports the feasibility of passive kidney thermometry for VUR detection.

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“…Application of MW radiometry in medicine include breast cancer detection [14, 15], brain temperature monitoring in newborn infants [16–18], ablation and hyperthermia temperature monitoring [19–22], cerebral temperature monitoring and brain functional imaging [23, 24]. A typical MW radiometer gathers thermal radiation from biological tissues using an antenna in the lower spectrum of the microwaves (1–5 GHz).…”

Section: Introductionmentioning

confidence: 99%

Modeling the detectability of vesicoureteral reflux using microwave radiometry

et al. 2010

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We present the modeling efforts on antenna design, frequency selection and receiver sensitivity estimation to detect vesicoureteral reflux (VUR) using microwave (MW) radiometry as the warm urine from the bladder maintained at fever range temperature using a MW hyperthermia device reflows into the kidneys. Radiometer center frequency (f c ), frequency band (Δf), and aperture radius (r a ) of the physical antenna for kidney temperature monitoring are determined using a simplified universal antenna model with circular aperture. Anatomical information extracted from computed tomography (CT) images of children age 4-6 years is used to construct a layered 3D tissue model. Radiometric antenna efficiency is evaluated in terms of the ratio between the power collected from the target at depth and the total power received by the antenna (η). Power ratio of the theoretical antenna is used to design a microstrip log spiral antenna with directional radiation pattern over f c ± Δf/2. Power received by the log spiral from the deep target is enhanced using a thin low-loss dielectric matching layer. A cylindrical metal cup is proposed to shield the antenna from electromagnetic interference (EMI). Transient thermal simulations are carried out to determine the minimum detectable change in antenna brightness temperature (δT B ) for 15-25 mL urine refluxes at 40-42°C located 35 mm from the skin surface. Theoretical antenna simulations indicate maximum η over 1.1-1.6 GHz for r a = 30-40 mm. Simulations of the 35 mm radius tapered log spiral yielded higher power ratio over f c ± Δf/2 for the 35-40 mm deep targets in the presence of an optimal matching layer. Radiometric temperature calculations indicate δT B ≥ 0.1 K for the 15 mL urine at 40°C and 35 mm depth. Higher η and δT B were observed for the antenna and matching layer inside the metal cup. Reflection measurements of the log spiral in saline phantom are in agreement with the simulation data. Numerical study suggests a radiometer with f c =1.35 GHz, Δf = 500 MHz and detector sensitivity better than 0.1 K would be the appropriate tool to noninvasively detect VUR using the log spiral antenna.

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Microwave radiometric imaging (MWI) for the characterisation of breast tumours

Cited by 30 publications

References 6 publications

Development of Anatomically Realistic Numerical Breast Phantoms With Accurate Dielectric Properties for Modeling Microwave Interactions With the Human Breast

Development of Anatomically Realistic Numerical Breast Phantoms With Accurate Dielectric Properties for Modeling Microwave Interactions With the Human Breast

Detection of Vesicoureteral Reflux Using Microwave Radiometry—System Characterization With Tissue Phantoms

Modeling the detectability of vesicoureteral reflux using microwave radiometry

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