Microwave-induced One-pot Synthesis of 2,4,5-trisubstituted Imidazoles Using Rochelle Salt as a Green Novel Catalyst

Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5‐Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease

“…Products were purified by recrystallization from methanol. [46] [47] [41] [48] [48] (3e). [49] [41] [41] [41] [41] [33] [50] [49]…”

Synthesis, Characterization, and Catalytic Properties of Magnetic Fe3O4@FU: A Heterogeneous Nanostructured Mesoporous Bio-Based Catalyst for the Synthesis of Imidazole Derivatives

“…Meanwhile imidazoles, polar in nature and with a five-member ring structure, are one of the most important compounds showing a wealthy source of biologically important features such as inhibitors, fungicides, herbicides plant, anti-inflammatory, anticancer, antimicrobial, analgesic, and anti-tubercular activity (Shalini et al, 2010 ; Varzi and Maleki, 2019 ). Numerous approaches have been developed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles, which can be prepared by a four-component cyclo condensation consisting of aldehyde, benzil, a primary amine and ammonium acetate in the presence of different catalysts such as BF 3 ·SiO 2 (Sadeghi et al, 2008 ), and silica gel/NaHSO 4 (Karimi et al, 2006 ), while other main components are achieved by synthesis of tri-substituted imidazoles by the condensation of benzil derivatives, aryl aldehydes, and ammonium acetate catalyzed by different catalysts such as ZrCl 4 (Shitole et al, 2015 ), sulfanilic acid (Gadekar et al, 2009 ), and chitosan (Zheng et al, 2019 ). However, some of these methodologies have some drawbacks, such as low yields, long reaction times, severe reaction conditions, and work up procedure.…”