Microwave-induced hydrolysis of phospho anhydride bonds in nucleotide triphosphates

Sun, Wei; Guy, Pamela M.; Jahngen, Jessica H.; Rossomando, Edward F.; Jahngen, Edwin

doi:10.1021/jo00253a047

Cited by 76 publications

(53 citation statements)

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“…To our knowledge, only few papers on organic syntheses under MI at low temperature have been reported. Bose et al (1991), Sun et al (1988) and Lewis et al (1992) reported the athermal action of MI on organic synthesis at low temperature. Huang et al (1996a b) studied the kinetics theory of MI on chemistry synthesis at different temperatures.…”

Section: Introductionmentioning

confidence: 99%

Low-temperature synthesis of allyl dimethylamine by selective heating under microwave irradiation used for water treatment

Tian

Zhang

2005

Radiation Physics and Chemistry

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Low-temperature synthesis of allyl dimethylamine (ADA) by selective heating under microwave irradiation (MI) used for water treatment is investigated. The effect of MI, ultrasound irradiation (UI) and conventional heating on yield of ADA, reaction time and the flocculation efficiency of polydiallyl dimethylammunion chloride (PDADMAC) prepared form ADA were studied. The results show that by selective heating at low temperature, MI not only increases yield of ADA and reduces reaction time, but also greatly enhances the flocculation efficiency of PDADMAC. r

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Section: Introductionmentioning

confidence: 99%

Low-temperature synthesis of allyl dimethylamine by selective heating under microwave irradiation used for water treatment

Tian

Zhang

2005

Radiation Physics and Chemistry

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“…It has been reported that certain reactions such as Diels-Alder [15,16], ethenoid [17], Claisen reaction [18], Fischer cyclization [19], synthesis of heterocycles [20], hydrolysis of esters [21,22], phosphoanhydride [23] and adenosine triphosphate formation [24], rapid hydrogenation [25], deprotection of benzyl esters [26], deacetylation of diacetates [27], Graebe-Ullmann synthesis [28], oxazoline formation [29,30], Knoevengel condensation [31], and aromatic ether formation [32,33] could be facilitated by microwave irradiation. However, to the best of our knowledge, no such application has been devised for the previously described Mannich-type reaction.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of cyclic esters of N-toluenesulfonyl ?-aminophosphonic acid

Dai

Chen

1998

Heteroatom Chem.

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“…In the laboratory, the microwave generator used early on was a laboratory-grade instrument; for example, in 1993, Lagana et al (32) described the analysis of sialic acids using the Microwave Digestion System (CEM Co.). More recently, household microwave ovens have been used for chemical analysis of protein, lipid, and sugar structures in the laboratory (33)(34)(35)(36)(37)(38). In our laboratory, a household microwave oven has been used for fatty acid compositional analysis of phospholipids and glycosphingolipids, as well as for carbohydrate structural analysis of glycosphingolipids (10,18).…”

Section: Discussionmentioning

confidence: 99%

Microwave-mediated analysis for sugar, fatty acid, and sphingoid compositions of glycosphingolipids

Itonori

Takahashi

Kitamura

et al. 2004

Journal of Lipid Research

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For chemical characterization of glycosphingolipids, it is necessary to determine the chemical compositions of three constituents, i.e., sugars, fatty acids, and sphingoids. A new rapid analytical method is described using a one-pot reaction in a household microwave oven, producing sugars, fatty acids, and especially sphingoids free of byproducts, from a single aliquot of a biological sample. Glycosphingolipids were hydrolyzed by microwave exposure with 0.1 M NaOH/CH 3 OH for 2 min followed by 1 M HCl/ CH 3 OH for 45 s. The alkaline methanolysis step produced intermediate lysoglycosphingolipids virtually free of byproducts such as the O -methyl ethers usually seen. The fatty acid methyl esters were extracted with n-hexane, and other reaction products were dried, taken up in aqueous alkaline methanol, and shaken with chloroform. Sphingoids partitioned into the organic phase under these conditions, whereas the sugar portion that partitioned into the aqueous phase was re-N -acetylated and remethanolyzed for 30 s by microwave exposure.Analysis of the profiles of glycosphingolipid constituents obtained using the microwave oven method showed that they were quantitatively and qualitatively comparable to those obtained by time-consuming conventional methods, which require reaction for several hours. Analysis of the three constituents, including analysis by gas chromatography, may be obtained within 1 day using the method described here.

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Microwave-induced hydrolysis of phospho anhydride bonds in nucleotide triphosphates

Cited by 76 publications

References 0 publications

Low-temperature synthesis of allyl dimethylamine by selective heating under microwave irradiation used for water treatment

Low-temperature synthesis of allyl dimethylamine by selective heating under microwave irradiation used for water treatment

Synthesis of cyclic esters of N-toluenesulfonyl ?-aminophosphonic acid

Microwave-mediated analysis for sugar, fatty acid, and sphingoid compositions of glycosphingolipids

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