Microwave-induced ferrier rearrangement of hyroxy beta-lactams with glycals

Abstract

Microwave-induced organic methods are extremely useful in synthetic organic chemistry for the preparation of molecules. A combination of irradiation and high temperature is probably responsible to obtain the final product in an accelerated process. This review focuses on a crucial nucleophilic reaction using hydroxy beta-lactams as the starting compounds. Specifically, the reaction of cis- and trans-hydroxy beta-lactams with different types of glycals under microwave irradiation using iodine as the catalyst is explored. This reaction produces unstaturated glycosides through Ferrier Rearrangement.