Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives

Chhatbar, Mahesh U.; Meena, Ramavatar; Prasad, Kamalesh; Chejara, Dharmesh R.; Siddhanta, A. K.

doi:10.1016/j.carres.2011.01.002

Cited by 35 publications

(31 citation statements)

References 43 publications

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“…After cooling, the solution was dialyzed against DM water for 48 h (changing the water four times), using a 1200 molecular weight cut‐off dialysis tube. Then, this mixture was lyophilized to obtain the alginic‐acid‐based monoamido amino acid ( Scheme ) …”

Section: Methodsmentioning

confidence: 99%

“…Water‐soluble fluorescent polymers, for example, alginic‐acid‐based monoamido amines were reported, which were known to be useful tracers for acting as analogs in understanding the behavior of biological macromolecules …”

Section: Introductionmentioning

confidence: 99%

“…Ethylenediamine‐modified polysaccharides can be used in efficient gene delivery to mesenchymal stem cells, in the transport of CO 2 as cation‐exchange membrane . The modified polysaccharides also show fluorogenic properties with potential utility in biomedical applications …”

Section: Introductionmentioning

confidence: 99%

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Protein‐Mimicking Functions of Nano‐Size Monoamido Amino Acids Derived from Polysaccharides of Marine Origin

Chadar

Chudasama

Vadodariya

et al. 2019

Macro Chemistry & Physics

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Polysaccharides of marine origin, for example, agarose (Ag) and alginic acid (Alg)-based new nano-size monoamido amino acid derivatives are synthesized and their protein-like characteristics are evaluated. Two new agarosebased nanosize amino acid derivatives are obtained by partial amidation of agarose succinate half-ester (Ag-SA; DS 0.95) employing aliphatic acyclic and cyclic diamines, for example, 1,6-hexamethylenediamine (HDA) and trans-1,4-cyclohexanediamine (CHDA), named Ag-SA-hexamethylenemonoamido (AEAm) and Ag-SA-cyclohexanemonoamido (AECAm) amines (DSs 0.47, 0.35), recording isoelectric points (pIs) 7.9 and 6.4, respectively. Alginic acid, extracted from the Indian seaweed species, Sargassum tenerrimum, is functionalized with ethylene diamine (EDA) affording a nanosize alginic-acid-based monoamido amino acid (Alg-EDA; DS 0.47; pI 3.40). All of these three nanosize monoamido amino acids (DLS; (nm) AEAm 0.65, 80.9; AECAm 0.65, 7.54, and 107.4; Alg-EDA 0.89, 2.0, 50, and 61.0) exhibit protein-mimicking functions interacting with Salman testes DNA and bovine serum albumin (BSA), displaying different complexation and decomplexation profiles in a varying pH regime. These nanobody polysaccharide-based protein-like large molecules may be of potential utility in the domains of pH-responsive drug delivery, separations as well as chiral sensing applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Protein‐Mimicking Functions of Nano‐Size Monoamido Amino Acids Derived from Polysaccharides of Marine Origin

Chadar

Chudasama

Vadodariya

et al. 2019

Macro Chemistry & Physics

Self Cite

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show abstract

“…The reaction mixture was stirred at room temperature for 1 h. A solution of BO2 (125.6 mg, 0.505 mmol) dissolved in distilled water (70 mL) was added to the reaction mixture. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was precipitated in isopropyl alcohol and washed twice with isopropyl alcohol [15,[26][27][28][29][30].…”

Section: Synthesis Of Alginate Modified With Bo2 (Abo)mentioning

confidence: 99%

Simultaneous detection and removal of radioisotopes with modified alginate beads containing an azo-based probe using RGB coordinates

Jang

Namgung

et al. 2015

Journal of Hazardous Materials

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“…To avoid the water-dispersive nature of alginic acid, it is often converted into its amide or crosslinked with suitable crosslinkers. Siddhanta and co-workers [69] reported a facile MW-assisted method for the synthesis of such water-soluble fluorescent alginic acid amides (333) employing different diamines in water (Scheme 19.67).…”

Section: Synthesis Of Analogs Of Natural Productsmentioning

confidence: 99%

Microwaves in the Synthesis of Natural Products

Eycken¹,

Bariwal²,

Bariwal³

2012

Microwaves in Organic Synthesis

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Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives

Cited by 35 publications

References 43 publications

Protein‐Mimicking Functions of Nano‐Size Monoamido Amino Acids Derived from Polysaccharides of Marine Origin

Protein‐Mimicking Functions of Nano‐Size Monoamido Amino Acids Derived from Polysaccharides of Marine Origin

Simultaneous detection and removal of radioisotopes with modified alginate beads containing an azo-based probe using RGB coordinates

Microwaves in the Synthesis of Natural Products

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