Microwave Coagulation Therapy with Interruption of Hepatic Blood Inor Outflow: An Experimental Study

Takamura, Manabu; Murakami, Takamichi; Shibata, Takashi; Ishida, Takeshi; Niinobu, Takahiro; Kawata, Shigeto; Shimizu, Junzo; Kim, Tonsok; Monden, Morito; Nakamura, Hajime

doi:10.1016/s1051-0443(07)61487-0

Cited by 35 publications

(17 citation statements)

References 20 publications

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“…Complete ablation of tumours surrounding major hepatic vessels (without vascular occlusion) using microwave radiation through a triple antenna has been reported [22]. In-vivo studies, however, have shown that temporary occlusion of hepatic inflow mechanically can augment the effect of ablation [46,47]. Shibata et al [47] randomized 25 and 31 patients, respectively, to MWA with or without vascular occlusion, and found that the latter group achieved a larger area of ablation and the local recurrence rate was significantly lower at 7% compared with 45% in those who received MWA without vascular occlusion.…”

Section: Principles Of Microwave Ablation and Its Applicationmentioning

confidence: 99%

Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic review

Ong

Gravante

Metcalfe

et al. 2009

European Journal of Gastroenterology & Hepatology

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This article reviews the therapeutic efficacy and complications of microwave ablation (MWA) in the treatment of primary and secondary liver malignancies. A PubMed search using keywords 'microwave', 'liver', 'malignancy', 'cancer' and 'tumour' was performed to identify articles related to MWA of liver malignancies published in English from 1975 to February 2008. MWA is an effective treatment options for both primary and secondary liver malignancies with survivals comparable with those of liver resections. Local recurrences can be managed with further ablation. Small tumour size, well-differentiated tumour and a reduced number of lesions are factors associated with good prognosis. Temporary occlusion of the portal venous and hepatic arterial flow may increase the size of ablation but the safety aspect requires further validation. MWA is a minimally invasive technique that has broadened the therapeutic option for patients with conventionally unresectable liver tumours with promising survival data. Future advances in the applicator design and treatment monitoring may further improve its efficacy and widen the indications.

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Section: Principles Of Microwave Ablation and Its Applicationmentioning

confidence: 99%

Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic review

Ong

Gravante

Metcalfe

et al. 2009

European Journal of Gastroenterology & Hepatology

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“…Facilitating hepatic resection by blood flow interruption becomes of significance in facilitating minimally invasive or robotic techniques. However, blood flow interruption in the liver may have wider implications in the fields of ablative therapies for liver masses and for chemotherapy and gene therapy 12,13 . Blood flow interruption to enhance ablative therapies for liver tumours has been advocated but hindered by the absence of a safe and simple means of providing it 14 .…”

Section: Discussionmentioning

confidence: 99%

Feasibility of bloodless liver resection using Lumagel, a reverse thermoplastic polymer, to produce temporary, targeted hepatic blood flow interruption

Pomposelli¹,

Akoad²,

Flacke

et al. 2012

HPB

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“…However, Lencioni et al showed that the use of local thermal ablation techniques such as radiofrequency (RF) results in superior local recurrence-free survival rates in comparison to percutaneous ethanol injection (PEI) for the treatment of small hepatocellular carcinoma (HCC) in patients with cirrhosis [28]. Likewise, TACE combined with other local ablative treatment options such as MR-guided LITT or radiofrequency (RF) ablation increases the effectiveness of the treatment, and better results were observed with the combined protocol than with either of these therapies alone [32,[43][44][45][46]. Consequently, experimental studies also found that temporary interruption of blood flow to the liver significantly increased the coagulated area during the laser treatment [33,47,48].…”

Section: Discussionmentioning

confidence: 99%

Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)

et al. 2006

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This study aims to evaluate the efficacy and safety of a neoadjuvant treatment protocol with repeated transarterial chemoembolization (TACE) before MR-guided laser-induced thermotherapy (LITT) for large-sized hepatocellular carcinomas (HCC). Repeated TACE (mean, 3.5 treatments per patient) was performed in 48 patients with neoadjuvant intention (the largest lesion was between 50 and 80 mm in diameter, and there were no more than five lesions). For the TACE treatment, we used 10 mg/m(2) mitomycin, 10 ml/m(2) Lipiodol and microspheres. The tumor volume was measured by MRI. Lipiodol retention of the tumors was evaluated with CT. After the diameter of the tumors had decreased to less than 50 mm, the patients were treated with MR-guided LITT 4 to 6 weeks after embolization. Repeated TACE reduced the tumor size in 32 patients (66.7%), forming the basis for performing MR-guided LITT procedures. These patients received one to four laser treatments (mean, 1.9 per patient) for tumor ablation, resulting in a median survival of 36.0 months after the first treatment. For the remaining patients, no reduction in tumor size was achieved in 12 patients and disease progression in 4 patients. Neoadjuvant TACE appears to be an effective treatment of large-sized HCC, which extends the indication for MR-guided LITT.

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Microwave Coagulation Therapy with Interruption of Hepatic Blood Inor Outflow: An Experimental Study

Cited by 35 publications

References 20 publications

Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic review

Efficacy and safety of microwave ablation for primary and secondary liver malignancies: a systematic review

Feasibility of bloodless liver resection using Lumagel, a reverse thermoplastic polymer, to produce temporary, targeted hepatic blood flow interruption

Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)

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