“…Schiff bases have been important candidates owing to their coordination chemistry, and they can be synthesized and used as ligands in building complex with different metal ions. On the other hand, Schiff bases have been interested with a broad spectrum of biological and pharmacological activities, such as antibacterial, DNA binding, anti HIV, Largicidal, antifertility, anticancer, and anti-inflammatory activities [16][17][18][19][20][21][22][23]. The broad-spectrum biological activities of Schiff bases have been attributed to the -C = N-imine bond, where the electrophilic carbon and nucleophilic nitrogen provide excellent binding characters with different nucleophiles and electrophiles, resulting in the inhibition of targeted diseases, enzymes, or DNA replication [24].…”