Microwave-Assisted Synthesis, Spectral and Biopotential Characterization of Cr(III), Cu(II) and Zn(II) Complexes with 4-Aminothiophenol and Benzoate Ion

Abstract

Bioactive metal complexes of Cr(III), Cu(II), and Zn(II) were synthesized with 4-aminothiophenol and benzoate ion under microwave irradiation. The synthesized metal chelates were characterized by physical, spectral, biological studies. The geometry and magnetism of all the complexes were monitored by electronic spectra and magnetic studies. The metal complexes possess the metal-ligand ratios is in the order of 1:3:3 metal:ligand1:ligand2 for Cr(III), 1:2:2 metal: ligand1:ligand2 for Cu(II) and Zn(II) complexes were predicted based on the elemental analysis and metal estimation. The synthesized metal chelates are monomeric and neutral in nature and they show well redox properties based on the results of conductivity and electrochemical studies. Octahedral geometry of Cr(III), tetragonal geometry of Cu(II) and square planar geometry of Zn(II) complexes confirmed by IR, far-IR, NMR and EPR spectral studies. The crystalline nature and lattice parameters of Zn(II) complex were predicted by using the X-ray diffraction powder method. Biopotential activities of 4-aminothiophenol compared with metal chelates and standard drug namely chloramphenicol for bacterial and fluconazole for fungal strain by Agar disc diffusion method using Streptococci, Shigella and C. albicans. The results of DNA cleavage of pBR322 DNA and binding nature of ct-DNA to Cr(III) complex possess the binding and cleavage nature of them by predicting the binding constant of the metal complex.