Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities

El‐Borai, Mohamed A.; Rizk, Hala F.; Beltagy, Doha M.; El-Deeb, Ibrahim Yussif

doi:10.1016/j.ejmech.2013.04.043

Cited by 68 publications

(25 citation statements)

References 38 publications

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“…As a continuation of our research interest on the application of eco‐friendly techniques , we report here environmentally benign conditions as microwave irradiation, ultrasonic irradiation, and ball‐milling techniques. It is worthy that the results of some eco‐friendly methods gave higher yields in short time compared with conventional method as shown in (Table ).…”

Section: Resultsmentioning

confidence: 99%

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An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

El‐Borai

Rizk

Ibrahim

et al. 2019

Journal of Heterocyclic Chem

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5‐Amino‐3‐phenyl‐1‐(2,4,6‐trichlorophenyl)‐1H‐thieno[3,2‐c]pyrazole‐6‐carbonitrile (2) was designed and synthesized by one‐pot multicomponent reaction. Compound 2 was reacted with different reagents to obtain new condensed moieties with our thienopyrazole skeleton. The compounds were prepared by using environmentally benign techniques as microwave irradiation, ultrasonic irradiation, and ball‐milling. The structure of the prepared compounds was elucidated through spectroscopic methods. The new compounds were evaluated for their in vitro antibacterial and antifungal potentialities.

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Section: Resultsmentioning

confidence: 99%

“…In continuation of our efforts in the field of green chemistry , we report herein investigates a high‐yielding novel heterocyclic compounds having a thiophene moiety using ball‐milling technique under solvent‐free condition, microwave irradiation, and ultrasonic irradiation, which interesting as medicinal and biological properties.…”

Section: Introductionmentioning

confidence: 99%

An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

El‐Borai

Rizk

Ibrahim

et al. 2019

Journal of Heterocyclic Chem

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“…[1][2][3][4] For example, pyrazolopyridines exhibited various biological activities such as antimicrobial, antiinflammatory and antitumor. [4][5][6][7][8][9][10][11][12] (2a,b). A mixture of 3-(arylidene)-l-methyl-4-piperidone la,b (0.40 mol), 100 gm of anhydrous sodium acetate and 120 ml of acetic anhydride was stirred and heated under reflux for 12 hours.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Certain α,β-Unsaturated Ketones and their Corresponding Fused Pyridines

Hassan

Elhifnawi

Ahmed³

2019

Journal of Advanced Pharmacy Research

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Objective: This study aimed synthesis of fused pyridine due to the importance of these heterocycles as antimicrobial and anticancer. Method: Some novel substitutedpyrido[3,2-c]pyran-6-one,pyrido[2,3-c]isoxazole,pyrazolo[4,3-c] pyridine, pyrido[4,3-c]pyrimidine, pyrido[3,2-c]pyrimidine[2,3-b]triazine-2-thione and pyrido[3,2-c]pyrano[2,4-d] pyrimidine-2thione derivatives have been reported to possess various pharmacological activities like antimicrobial and antitumor.Results: A novel series of azoles and azines were designed and prepared via reaction of 3-(arylidene)-1-methy-4piperidonewith some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. Conclusion: It could be concluded that the tested compounds 14a,e, 13a, 11b and 17d1 have highest antibacterial activity . Compounds 11b, 13a, 14c,e,g, 16e, 17d1 have antifungal activity than antibiotic standard (Nystatin) used. Compound 13a and 25a have shown good anticancer agent.

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“…In view of these facts and in continuing effort to find synergistic cytotoxic activities, we report herein novel heterocyclic moieties fused with the thiazole ring with the hope that such moieties represent another biologically active scaffold with higher cytotoxic activity . The present work aims to synthesize novel thiazolopyrimidines, thiazolopyrimidinones, imidazolothiazoles, and 1‐thiazole‐5‐pyrazolone derivatives expected to have antioxidant, antitumor, and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

Microwave Assisted Synthesis of Fused Thiazoles in Multicomponent System and Their in vitro Antitumor, Antioxidant, and Antimicrobial Activities

El‐Borai

Rizk

Ibrahim

et al. 2016

Journal of Heterocyclic Chem

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Microwave-assisted synthesis of some new pyrazolopyridines and their antioxidant, antitumor and antimicrobial activities

Cited by 68 publications

References 38 publications

An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

Synthesis and Biological Evaluation of Certain α,β-Unsaturated Ketones and their Corresponding Fused Pyridines

Microwave Assisted Synthesis of Fused Thiazoles in Multicomponent System and Their in vitro Antitumor, Antioxidant, and Antimicrobial Activities

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