Microwave Assisted Synthesis of Some Novel Pyrimidine Derivative and Screening for their Biological Activity

Abstract

A substituted pyrimidine derivatives were synthesized from chalcone of 3-acetyl-2,5-dimethyl thiophene with corresponding active aldehyde in microwave oven. The newly synthesized compounds were characterized by TLC, IR, 1H NMR, 13C NMR spectral analysis. Pyrimidine derivative were screened for their antibacterial activity in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration (MIC) was carried with the reference of standard drugs amoxicillin, ampicillin and ciprofloxacin. The pyrimidine derivatives shows better inhibiting action against both types of bacteria (Gram-positive and Gram-negative) compared to amoxicillin, ampicillin and ciprofloxacin standard drugs.