Microwave-assisted synthesis of pyrido[1,2-a]benzimidazole derivatives of β-aryloxyquinoline and their antimicrobial and antituberculosis activities

Sangani, Chetan B.; Jardosh, Hardik H.; Patel, Manish P.; Patel, Ranjan G.

doi:10.1007/s00044-012-0322-5

Cited by 32 publications

(12 citation statements)

References 32 publications

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“…There has been an increased interest in the investigation of antimicrobial activities of 2‐substituted benzofuran derivatives . Also, benzimidazole derivatives show antiparasitic, antibacterial, anthelmintic, analgesic, anti‐inflammatory, anticancer and antitubercular activities. The structural diversity of the moieties as well as their biological and pharmaceutical importance have motivated research to develop new classes of benzofuran‐substituted benzimidazoles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Kokare

Naik

Nevrekar

et al. 2016

Applied Organom Chemis

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Mononuclear divalent complexes of Co, Ni, Cu and Zn derived from a benzofuran‐based novel hydrazone tridentate ligand were synthesized and characterized using various spectroscopic methods. Elemental analysis reveals that the metal‐to‐ligand ratio is 1:2 which is supported by mass spectrometry results. Conductivity measurements suggest that all the complexes are non‐electrolytic in nature. The ligand and complexes were evaluated for their antimicrobial potency. Bioassay of all hydrazone chelates shows enhanced activity as compared to that of the ligand. The complex with cobalt ion as the metal centre shows better activity against fungi than the standard. Also, ligand and complexes were screened for antituberculosis activity; some analogues (Ni, Cu, Zn) are eight times more active than the standard. Both ligand and complexes show moderate ability to cleave calf thymus DNA. Copyright © 2015 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Kokare

Naik

Nevrekar

et al. 2016

Applied Organom Chemis

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“…The fluoro and cyano groups substituted compound 56 and 57 showed slow onset inhibition of InhA with identical MIC values of 0.313 μg/mL against M. tuberculosis . Patel and co‐worker found that pyrido[1,2‐ a ]benzimidazole derivatives 58 and 59 displayed inhibition of 97% and 96%, respectively, at MIC value of 6.25 μg/mL . Kini et al.…”

Section: Diarylethersmentioning

confidence: 97%

“…70 Patel and co-worker found that pyrido[1,2-a]benzimidazole derivatives 58 and 59 displayed inhibition of 97% and 96%, respectively, at MIC value of 6.25 g/mL. 71 76 It was observed that the 1,4-dihydropyridine-3, was higher than standard drug isoniazid (0.03 g/mL). 80 In another report, the same group of researchers showed that the compound 71 containing a 2-chlorophenyl moiety on the nitrogen atom of 1,4-dihydropyridine ring displayed MIC value of 0.02 g/mL.…”

Section: Diarylethersmentioning

confidence: 99%

New structural classes of antituberculosis agents

Kumar

Patel

Jain

2017

Medicinal Research Reviews

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Tuberculosis (TB), one of the deadliest diseases is shattering the health and socioeconomic status of the society. The emergence of multidrug resistant (MDR) and extremely drug resistant (XDR) strains has provided unprecedented lethal character to TB. The development of MDR and XDR strains of TB results in more deaths, longer duration of therapy, and appearance of the disease in the immunocompromised patients. Because of the development of rapid resistance by Mycobacterium tuberculosis, researchers are confronted with serious challenges in combating TB. For instance, the need for potency and specificity in therapeutic agents approaching clinics, and the increasing demand of low toxicity due to long duration of treatment. Recently, it is proposed that such challenges could be addressed by a shift from contemporary or known classes of drugs to new scaffold-containing or entirely new structural classes of drugs that possibly act on the previously unknown targets, resulting in possibly less instances of resistance development. The exploitation of advances made in the biology of TB in the last and present decades have created opportunities to discover a large number of new structural classes that specifically targets TB by molecular mechanism of action(s) unknown earlier. We have earlier reviewed new structural classes of anti-TB agents up to year 2005. This review covers literature reports of the subsequent 10 years on the discovery of new structural classes of synthetic anti-TB agents. Due to the availability of large number of research reports, we have divided new compounds in 38 structural classes, 368 structures, and 307 references.

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“…[69] These derivatives weref ound to possess variousb iological activities. [69] These derivatives weref ound to possess variousb iological activities.…”

Section: Othersmentioning

confidence: 99%

Recent Development of Benzimidazole‐Containing Antibacterial Agents

Song

2016

ChemMedChem

121

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Clinically significant antibiotic resistance is one of the greatest challenges of the twenty-first century. However, new antibacterial agents are currently being developed at a much slower pace than our growing need for such drugs. Given their diverse biological activities and clinical applications, many bioactive heterocyclic compounds containing a benzimidazole nucleus have been the focus of interest for many researchers. The benzimidazole nucleus is a structural isostere of naturally occurring nucleotides. This advantage allows benzimidazoles to readily interact with the various biopolymers found in living systems. In view of this situation, much attention has been given to the exploration of benzimidazole-based antibacterial agents, leading to the discovery of many new chemical entities with intriguing profiles. In this minireview we summarize novel benzimidazole derivatives active against various bacterial strains. In particular, we outline the relationship between the structures of variously modified benzimidazoles and their antibacterial activity.

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Microwave-assisted synthesis of pyrido[1,2-a]benzimidazole derivatives of β-aryloxyquinoline and their antimicrobial and antituberculosis activities

Cited by 32 publications

References 32 publications

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

Synthesis and spectroscopic characterization of transition metal complexes derived from novel benzofuran hydrazone chelating ligand: DNA cleavage studies and antimicrobial activity with special emphasis on antituberculosis

New structural classes of antituberculosis agents

Recent Development of Benzimidazole‐Containing Antibacterial Agents

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