Microwave-assisted synthesis of N,N-bis-(2-pyridylmethyl)amine derivatives. Useful ligands in coordination chemistry

Pimentel, Luiz Cláudio Ferreira; Souza, Andréa Luzia F. de; Fernandez, Tatiana L.; Wardell, James L.; Antunes, O. A. C.

doi:10.1016/j.tetlet.2006.11.154

Cited by 11 publications

(2 citation statements)

References 33 publications

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“…Molecule 3 was readily obtained from the cross-coupling reaction of the N-(3-Propionic acid) bis(2pyridylmethyl) amine 1 with the cleaved DCPC 2 in 53% yield. 1 was prepared according to reported procedures (Bhattacharya et al;2003, Pimentel et al, 2007Wong et al, 2010) from 2-pyridinecarboxaldehyde in three steps affording the target compound in 97% overall yield. 10,12-tricosadiynoic acid -[ 1-(hydroxymethyl)-1,2-ethanediyl] ester 2 (DC-OH) lipids were obtained after cleavage of the commercially available DC8,9PC phosphocholine head-group by enzymatic reaction using phospholipase C according to Nguyen et al procedure (Nguyen, 2014).…”

Section: Resultsmentioning

confidence: 99%

Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric

Kenaan

Brunel

Raimundo

et al. 2020

Sensors and Actuators B: Chemical

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The development of ions sensors with low limit of detection and high sensitivity and selectivity is required in many fields of application and still remains a challenge. We report on the first dual-gated field effect transistor sensor with an engineered lipid monolayer as top gate dielectric. The sensor was designed and fabricated for the specific detection of Cu 2+ using the Di-2-picolylamine as recognition unit. The lipid monolayer was reticulated to achieve high mechanical and dielectric stability over device operation. The resulting sensor exhibits exceptional performances with a limit of detection at 10 femtomolar, with a linear dependency over 10 decades and a super-Nernstian sensitivity of ~100 mV/decade. We also show that the lipid layer forms a good barrier to ions trapping, hence providing a high stability of the sensor over measurements.

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Section: Resultsmentioning

confidence: 99%

Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric

Kenaan

Brunel

Raimundo

et al. 2020

Sensors and Actuators B: Chemical

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“…Focused MW flash heating as a nonconventional energy source, showing different temperature gradients and automated, has recently been proven to be very effective in accelerating organic reactions [16]. The application of MWs opens up many opportunities to improve monomer and polymer preparation and enhances polymer reactions [17, 18]. The purpose of this research is to synthesize PEEKs with the MW‐heating method to produce polymers with good thermal stability and to study how the isomers affect the polymer properties.…”

Section: Introductionmentioning

confidence: 99%

Microwave promoted synthesis and characterization of isomeric poly(ether ether ketone)s

Zhang

Yin

et al. 2010

Polymer Engineering & Sci

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A series of isomeric poly(ether ether ketone)s were synthesized using microwave‐assisted method by nucleophilic substitution reaction of hydroquinone and 4,4′‐biphenol with 4,4′‐difluorobenzophenone (DFBP) or 2,4′‐DFBP in the presence of anhydrous K2CO3. The polymers with inherent viscosities in the range of 0.20–0.71 dlg−1 were obtained in quantitative yields and had excellent thermal stability as shown by the temperature of 5% weight loss in nitrogen above 410°C. X‐ray diffraction patterns confirmed the semicrystalline character of some of the polymers. The results also indicate that the reaction time was shortened remarkably and the reaction temperature could be controlled easily. POLYM. ENG. SCI., 2011. © 2010 Society of Plastics Engineers

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Synthesis of a Phosphinate Analogue of the Antitumour Phospholipid Edelfosine

Markoulides

Regan

2015

Eur J Org Chem

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The first concise synthesis of a phosphinate analogue of the antitumour ether phospholipid edelfosine is described. The key synthetic step comprised the free‐radical addition reaction of phosphinic acid to a functionalised allyl ether, to incorporate the hydrophobic tail into a monosubstituted H‐phosphinic acid. The hydrophilic head group was then added by using a silyl phosphonite based Michael addition. The reported synthetic study lays the groundwork for the synthesis of modified phosphinate phospholipid derivatives to facilitate investigations on their biological activity as membrane‐targeting antitumour agents.

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Microwave-assisted synthesis of N,N-bis-(2-pyridylmethyl)amine derivatives. Useful ligands in coordination chemistry

Cited by 11 publications

References 33 publications

Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric

Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric

Microwave promoted synthesis and characterization of isomeric poly(ether ether ketone)s

Synthesis of a Phosphinate Analogue of the Antitumour Phospholipid Edelfosine

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