MICROWAVE ASSISTED SYNTHESIS OF IMIDAZO[1,2-a]- [1,8]NAPHTHYRIDIN-1(2H)-ONES

Synthesis of 1,2,4-triazolo[4,3-a][1,8]Naphthyridines using Chloranil under Microwave Irradiation

“…as energy transfer media which absorb microwave energy efficiently through dipole rotation. In view of this and in continuation of our interest in microwave-assisted organic transformations on 1,8-naphthyridine derivatives, [18][19][20][21] we report here, a convenient, practical and efficient method for the synthesis of 1,2,4-triazolo [4,3-a] [1,8]naphthyridines using chloranil under microwave irradiation.…”

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

“…In this case, one of the imidazole nitrogen atoms is incorporated externally via a nucleophilic displacement reaction. For example, the imidazo[1,2-a]- [1,8]naphthyridine-1(2H)-one 188 was obtained in 85% overall yield by microwaveassisted condensation of 2-chloro-1,8-naphthyridine 186 with alanine (the external nitrogen source), followed by the dehydration and subsequent cyclization of amino acid 187 (Fig (45)) [288]. Compared to conventional heating methods, this two-step microwave-assisted procedure decreased reaction times from 7 h to 5 min and improved yields.…”

Microwave assisted synthesis of thiazolo[3,2‐b][1,2,4]‐triazoles containing 1,8‐naphthyridine moiety

“…as energy transfer media which absorb microwave energy efficiently through dipole rotation. In view of this and in continuation of our interest in microwave-assisted organic transformations on 1,8-naphthyridine derivatives [13][14][15][16][17], we report herein, a convenient, practical and efficient method for the synthesis of thiazolo [3,2b] [1,2,4]triazoles containing 1,8-naphthyridine moiety under microwave irradiation. (4).…”