Microwave-assisted synthesis of graphene modified CuO nanoparticles for voltammetric enzyme-free sensing of glucose at biological pH values

Abstract

The effect of graphene nanosheets on the glucose sensing performance of CuO powders was investigated. CuO and graphene-modified CuO nanoparticles (NPs) were fabricated by microwave-assisted synthesis and characterized by X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy. The material was placed on a glassy carbon electrode (GCE) which then was characterized by cyclic voltammetry and chronoamperometry with respect to the capability of sensing glucose both at pH 13 and pH 7.4. The results revealed that the modified GCE has a fast and selective linear response to glucose at pH 13 that covers the 0.21 μM to 12 mM concentration range, with a 0.21 μM low detection limit. The presence of graphene nanosheets results in an improved sensitivity which is to 700 μA mM cm. In solution of pH 7.4, the respective data are a linear analytical range from 5 to 14 mM; a 5 μM LOD and a sensitivity of 37.63 μA mM cm at working potential of -0.05 V (vs. Ag/AgCl) and scan rate of 50 mV s. Ascorbic acid, dopamine, uric acid, sucrose, maltose and fructose do not interfere. Graphical abstract ᅟ.

A Noninvasive Accurate Measurement of Blood Glucose Levels with Raman Spectroscopy of Blood in Microvessels

“…Optical methods, including microwave spectroscopy [11], optical coherence tomography [12,13], near-infrared (NIR) spectroscopy [14], polarimetry [15], Raman spectroscopy [16,17,18] and fluorescence techniques [19], have been considered as accurate and painless means of blood glucose detection. Among the distinct optical techniques used in glucose measurement, Raman spectroscopy is one of the most promising optical approaches [16,20].…”

Structural reorganization of CuO/Cu2[Fe(CN)6] nanocomposite: characterization and electrocatalytic effect for the hydrogen peroxide reduction

“…Electrochemical sensors are currently being used for the determination of analytes such as glucose (Ding et al 2019), H 2 S (Brown et al 2018), dopamine (Wang et al 2019), hydrogen peroxide (Bach et al 2019), and cholesterol (Thakur et al 2019). The use of CuO NPs facilitates the involvement of cationic species (Cu + , Cu 2+ , and Cu 3+ ) in applications close to 0 V in neutral, acidic, and basic media (Vázquez et al , Foroughi et al 2018. Equations (1)-(3) represent the formation of some of these species:…”

Cu(I) Coordination Complex Precursor for Randomized CuOx Microarray Loaded on Carbon Nanofiber with Excellent Electrocatalytic Performance for Electrochemical Glucose Detection

“…A preconcentration step that involved 10 minutes accumulation at open circuit potential before SWV running led to the lowest limit of detection and the highest sensitivity for glucose detection (5419.77 µA·mM −1 ·cm −2 at + 1.1 V vs. Ag/AgCl) vs. Cu-based electrodes reported to date in literature.to modify the electrode as a non-enzymatic sensor for glucose detection taking its low cost, suitable redox properties, and excellent stability into account [7]. A large variety of copper/copper oxides modified electrodes having various shapes and sizes of copper nanoparticles have been reported to date for the non-enzymatic detection of glucose [1,2,[7][8][9][10][11][12][13][14][15][16][17][18][19]. Moreover, the role of the carbon substrate in enhancing the electrochemical performance of the copper-based nanostructured carbon electrode has been investigated [20][21][22].…”

“…CNFs are cylindric nanostructures with graphene layers that are arranged as stacked cones, cups, or plates, with mechanical strength and electric properties being similar to carbon nanotubes while their size and graphite ordering can be well controlled [23]. They have been extensively used in electrochemical sensors and biosensors either as co-catalyst or/and catalyst support [9]. Indeed, they can be used both as immobilization matrixes for metal/metal oxides and as transducers due to their electrochemical signal [24][25][26].Recently, the construction of micro-/nano-structures assembly-based electrode compositions containing copper/copper oxides has been studied for enhancing the electrocatalytic properties and implicit, the electroanalytical performance for the non-enzymatic detection of glucose through the one-pot solvothermal method [8] and the copper-based metal-organic framework [1].Copper coordination complexes represent one of the largest classes containing copper with relevant photochemical and photophysical properties [27].…”

“…CNFs are cylindric nanostructures with graphene layers that are arranged as stacked cones, cups, or plates, with mechanical strength and electric properties being similar to carbon nanotubes while their size and graphite ordering can be well controlled [23]. They have been extensively used in electrochemical sensors and biosensors either as co-catalyst or/and catalyst support [9]. Indeed, they can be used both as immobilization matrixes for metal/metal oxides and as transducers due to their electrochemical signal [24][25][26].…”