Microwave Assisted Synthesis of Fused Heterocyclic Compounds

Srinivasan, Kumar; Chaskar, Pratip K.; Dighe, Satish N.

doi:10.3987/rev-11-696

Cited by 17 publications

(6 citation statements)

References 61 publications

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“…Only direct measurements [140,153] were available for the H-atom abstraction reaction via O2 (R41; 59/3), while the reaction CH2O + ȮH = HĊO + H2O (R40) was studied both experimentally [114,129,[154][155][156][157] 63/6and theoretically [154,158,159]. The theoretical results of Jasper et al [160] and direct measurements of rate coefficients [161][162][163][164] for the ĊH3 + HȮ2 reaction (R47/R53) were considered (sum of the two branches: 3/1, branch-specific: 57/5, including one direct measurement of R53 in reverse direction).…”

Section: Selection Of Rate Determinations Used As Optimization Targetsmentioning

confidence: 99%

Uncertainty quantification of a newly optimized methanol and formaldehyde combustion mechanism

Olm

Varga

Valkó

et al. 2017

Combustion and Flame

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A detailed reaction mechanism for methanol combustion that is capable of describing ignition, flame propagation and species concentration profiles with high accuracy has been developed. Starting from a modified version of the methanol combustion mechanism of Li et al. (Int. J. Chem. Kinet. 2007) and adopting the H2/CO base chemistry from the joint optimized hydrogen and syngas combustion mechanism of Varga et al. (Int. J. Chem. Kinet., 2016), an optimization of 57 Arrhenius parameters of 17 important elementary reactions was performed, using several thousand indirect measurement data points, as well as direct and theoretical determinations of reaction rate coefficients as optimization targets. The final optimized mechanism was compared to 18 reaction mechanisms published in recent years, with respect to their accuracy in reproducing the available indirect experimental data for methanol and formaldehyde combustion. The utilized indirect measurement data, in total 24,900 data points in 265 datasets, include measurements of ignition delay times, laminar burning velocities and species profiles captured using a variety of experimental techniques. In addition to new best fit values for all rate parameters, the covariance matrix of the optimized parameters, which provides a quantitative description of the temperature-dependent ranges of uncertainty for the optimized rate coefficients, was calculated. These posterior uncertainty limits are much narrower than the prior limits in the temperature range for which experimental data are available. The uncertainty of the self-reaction of HȮ2 radicals and important H-atom abstraction reactions from the methanol molecule are discussed in detail.

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Section: Selection Of Rate Determinations Used As Optimization Targetsmentioning

confidence: 99%

Uncertainty quantification of a newly optimized methanol and formaldehyde combustion mechanism

Olm

Varga

Valkó

et al. 2017

Combustion and Flame

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“…In recent years a great deal of attention has been paid to the application of microwaves (MW) to heterocycle synthesis. [8][9][10][11][12][13] Ever since Van Noorden's report in 2008 entitled "Microwaving myths", 14 in which several experts described the current status of MW-assisted chemistry, was published, new technological advances have been made that have broadened the applications of this type of irradiation in synthetic medicinal chemistry. In this same reference J. Moseley (Astra Zeneca) is quoted as saying: "virtually all new compounds now have their rst synthesis in a microwave" and this fact has acquired even more relevance four years on.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

et al. 2013

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“…[ 77 ] Indeed, the development of new drug formulations is mainly based on improving bioavailability and reducing the nonspecific distribution of a given therapeutic agent. [ 78 ] Recently, drug delivery systems using nanostructured biomaterials have been introduced as a remarkable alternative to the traditional drug delivery formulation (i.e., liposomes) due to their instability and limited drug‐loading capacity for numerous clinical treatments/therapies such as cancer therapy, immune therapy, and management of diabetes diseases, which require long term release and stability, responsive release, and even intracellular targeting delivery. [ 79 ]…”

Section: Biomedical Applications Of Cellulose‐based Biomaterialsmentioning

confidence: 99%

Cellulose‐Based Biomaterials: Chemistry and Biomedical Applications

Hasanin

2022

Starch Stärke

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This review represents a fresh survey about cellulose‐based biomaterial for biomedical application, in which certain features that are essential to design potential biomedical materials. It illustrates their functionalizations, benefits, properties, and applications in the biomedical. Cellulose is produced from plants and alternative sources such as bacteria, algae, and fungi as well as animals where tunicate is the only animal source of cellulose. Biomedical materials based on cellulose attracts attention due to its unique physicochemical features and high biocompatibility. Thus, cellulose‐based biomaterials have wide potential to be used in large scale biomedical applications as a pioneering material that may be used alone or with other additives. Additionally, they are used in several biomedical applications such as drug delivery, wound dressing, and tissue engineering. However, cellulose is not extensively used in the biomedical industrial field, this may be due to the limitations of the full studies and the limitation of availability of clinical trials. Moreover, the biomaterials based on cellulose are a potential substrate for the 3D bioprinting field where the tissues and organs can be designed as prototype production. For all these reasons, this work will highlight the recent developments in the preparation methods of cellulose‐based biomaterials and their derivatives.

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Microwave Assisted Synthesis of Fused Heterocyclic Compounds

Cited by 17 publications

References 61 publications

Uncertainty quantification of a newly optimized methanol and formaldehyde combustion mechanism

Uncertainty quantification of a newly optimized methanol and formaldehyde combustion mechanism

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

Cellulose‐Based Biomaterials: Chemistry and Biomedical Applications

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