Microwave-Assisted Synthesis of Bioactive Quinazolines and Quinazolinones

Abstract

This paper aims to review recent developments in the synthesis of quinazolines and quinazolinone derivatives under conditions that include the application of microwave heating in the ring forming step. Recently, two reviews on the synthesis and chemistry of natural and synthetic quinazolines and quinazolinones have been published. This review highlights significant examples where microwave heating has been either synthetically enabling or has provided a key advantage over conventional thermal methods. Wherever possible, this review will focus on chemistry carried out using monomode systems and well-designed type of instrumentation. The review is grouped according to the main heterocycle types in order of increasing complexity; commencing with quinazolines and their derivatives. The microwave-assisted synthesis of quinazolines and quinazolinones will be classified and based on the substitution patterns of the ring system. Syntheses of heterocyclic systems of particular biological or commercial interest are emphasized.

Phyto-Extracts in Wound Healing

“…Since the compounds from such plants considerably vary in chemical structure, a generalized structure for all these alkaloids could not be presented. However, presently much work is being done to synthesize newer antimicrobial compounds utilizing quinazoline and indole backbones (513)(514)(515).…”

2-(2-Chloro-8-methylquinolin-3-yl)-4-phenyl-1,2-dihydroquinazoline

“…For the preparation and applications of quinazoline and quinoline derivatives, see: Jenekhe et al (2001); Hoemann et al (2000); Connolly et al (2005); Besson et al (2007); Roma et al (2000); Chen et al (2001); Debache et al (2008Debache et al ( , 2009; Nemouchi et al (2012).…”

“…The transferable nature of its properties provides a strong rationale for the development of synthetic methods. Not surprisingly, considerable progress in synthetic methodology applicable to quinazoline alkaloids has been made during the past decade (Connolly et al, 2005;Besson et al, 2007). As part of our research in developing new efficient methods for heterocycles synthesis and also multicomponent reactions (Debache et al, 2008;Debache et al, 2009;Nemouchi et al, 2012), we decided to design some new molecules containing reactive fonctionnalities.…”

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview

“…In 2007, a review on the synthesis of bioactive quinazolines and quinazolinones was published, focusing only on the synthesis of heterocyclic systems of specific biological activities or commercially important compounds (Besson and Chosson, 2007). In 2017, a review entitled "Green approaches toward [the] synthesis of substituted quinazolines" appeared in the chemical literature (Devi et al, 2017).…”