Microwave Assisted Synthesis, Characterization of New Heterocyclic Compounds and Evaluation as Anti Breast Cancer

Abstract

A number of new heterocyclic compounds derived from vanillin dimer chalcones were prepared by Claisen–Schmidt Condensation using a microwave as a heat source in base medium as a catalyst. The structures and suggestion mechanisms of reaction of the new products were atrubuted to elementary and spectroscopic analysis. Additionally, in vitro anticancer compounds activity of (Z1, Z2, Z3, Z7, Z8 and Z9) and all of them showed high inhibition efficiency except (Z2) were evaluated with human breast cancer cell line (Cal51), and compared with stander anticancer drugs, according standard MTT assay. The synthesized heterocyclic compounds were characterized based on the chemical properties of thier and spectroscopic data (FTIR, 1H NMR, 13C MNR and CHN-S).