Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery

Abstract

The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.

Recent advances in metal–organic frameworks for stimuli-responsive drug delivery

“…The results demonstrated that CPO-27-Mg could adsorb aspirin and paracetamol with high drug loading in vitro . 116 In another study, Xue et al used microwave-assisted synthesis to fabricate MIL-100, and used it to load DOX to treat breast cancer. 117 Studies focusing on using microwave-synthesized MOFs for stimulus-responsive drug delivery are still fewer.…”

Understanding the Working Mechanism of the Novel HKUST-1@BPS Composite Materials as Stationary Phases for Liquid Chromatography

“…Their three-dimensional networks are composed of metal ions or small metal-oxide clusters as inorganic nodes connected through coordination bonds with polydentate organic molecule-linkers. MOF matrices show a number of outstanding properties, such as high crystallinity degree, large specific surface area and pore volume, and open pore structure, which is accessible for guest molecules as well as a possibility of the rational design of the framework due to the judicious choice of the inorganic nodes and organic linkers or their post-synthesis modification [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. These physicochemical characteristics make MOFs promising materials for versatile applications in adsorption, separation, and catalysis [ 24 , 25 , 26 , 27 , 28 ].…”