Microwave assisted synthesis and antimicrobial screening of fused triazoles

Abstract

In the present study, a series of N-{4- [(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-1,3thiazol-2-yl}-2-substituted amide derivatives (1a-d) were synthesized in good yields and characterized. The compounds were evaluated for their preliminary in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhosa and then were screened for antitubercular activity against Mycobacterium tuberculosis H37 Rv strain by the MABA assay method. The antibacterial data of the tested compounds indicated that compounds 6b, 6c, 8a, 8b and 8c showed better activity against bacteria compared to reference drugs. The in vitro antitubercular activity reports of compounds tested against M. tuberculosis strain H37 Rv showed better activity by 8a, 8b and 8c.