Microwave-Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-Triazole Moiety

Liu, Min; Shi, Yanhong; Wu, Hong‐Ke; Sun, Zheng; Liu, Xinghai; Li, Baoju; Zhang, Yonggang

doi:10.3390/app5041211

Cited by 9 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antifungal activities of all synthesized compounds at the concentration of 50 μg/ml were evaluated for their in vitro antifungal activities against the pathogenic fungi, including B. dothidea , Phompsis sp., and B. cinerea by the poison plate technique ( Min et al, 2016 ). All the compounds were dissolved in 1 ml dimethyl sulfoxide (DMSO) before mixing with 90 ml potato dextrose agar (PDA).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

Lan

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

In this study, 17 novel pyrimidine derivatives containing an amide moiety were synthesized. Then their in vitro antifungal activities against Botryosphaeria dothidea (B. dothidea), Phomopsis sp., and Botrytis cinereal (B. cinereal) were determined. A preliminary biological test showed that compounds 5-bromo-2-fluoro-N-(2-((2-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)phenyl)benzamide (5f) and 5-bromo-2-fluoro-N-(3-((2-methyl-6-(trifluoromethyl)pyrimidin-4-yl)oxy)phenyl)benzamide (5o) exhibited higher antifungal activity against Phomopsis sp., with an inhibition rate of 100% compared to that of Pyrimethanil at 85.1%. In particular, compound 5o exhibited excellent antifungal activity against Phompsis sp., with the EC50 value of 10.5 μg/ml, which was even better than that of Pyrimethanil (32.1 μg/ml). As far as we know, this is the first report on the antifungal activities against B. dothidea, Phomopsis sp., and B. cinereal of this series of pyrimidine derivatives containing an amide moiety.

show abstract

Section: Methodsmentioning

confidence: 99%

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

Lan

et al. 2021

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…The antifungal activities of the title compounds 6a – 6m against Sclerotinia sclerotiorum ( S. sclerotiorum ), Phytophthora infestans ( P. infestans ), Thanatephorus cucumeris ( T. cucumeris ), Gibberella zeae ( G. zeae ), Fusarium oxysporum ( F. oxysporum ), Cytospora mandshurica ( C. mandshurica ), Botryosphaeria dothidea ( B. dothidea ), and Phompsis sp. were evaluated at the concentration of 50 μg/mL (Min et al, 2016 ; Wu et al, 2019a , b ). The target compounds 6a – 6m (5 mg) were dissolved in dimethyl sulfoxide (1 mL) and sterile water (9 mL) before mixing with 90 mL potato dextrose agar (PDA) to generate a final concentration of 50 μg/mL.…”

Section: Experimental and Methodsmentioning

confidence: 99%

Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs

Chen

Fei

et al. 2020

Front. Chem.

View full text Add to dashboard Cite

In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs were synthesized via six-step reactions. Bioassay results showed that some of the synthesized compounds revealed good antifungal properties against Sclerotinia sclerotiorum, Phytophthora infestans, Thanatephorus cucumeris, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Botryosphaeria dothidea, and Phompsis sp. at 50 µg/mL, which were similar to those of Kresoxim-methyl or Pyrimethanil. Meanwhile, bioassay results indicated that the synthesized compounds showed a certain insecticidal activity against Spodoptera litura, Mythimna separata, Pyrausta nubilalis, Tetranychus urticae, Rhopalosiphum maidis, and Nilaparvata lugens at 200 µg/mL, which was lower than that of Chlorantraniliprole. To the best of our knowledge, this study is the first report on the antifungal and insecticidal activities of pyridylpyrazol amide derivatives containing a pyrimidine moiety.

show abstract

“…In 2015, three series of novel thioether derivatives containing a 1,2,4-triazole moiety (23-25, Figure 5) were designed and synthesized by Min et al [34], Qian et al [35], and Zheng et al [36]. The antifungal activity results showed that compound 23 (Figure 5) displayed the best relative control efficacy (61.3%) against C. cassiicola at 100 μg/mL in vivo, which was better than that of Chlorothalonil.…”

Section: Antifungal Activitymentioning

confidence: 99%

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

Yang²,

Wang

et al. 2021

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Thioether derivatives, an important synthetic strategy in drug discovery, are acquiring more importance in plant protection field in recent years because of their broad spectrum of agricultural activities, such as antifungal, antibacterial, insecticidal, acaricidal, nematocidal, antiviral, herbicidal, and plant growthregulating activity. Thioethers and their analogues have been an area of great interest in recent years. This review summarizes the structure and agricultural activities of the thioether derivatives as reported in the literature that mainly covers the past 10 years from 2010 to 2020 as well as may contribute to a better understanding of thioether derivatives as efficient agricultural agents and provide some ideas on the development of novel pesticides.

show abstract

Microwave-Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-Triazole Moiety

Cited by 9 publications

References 33 publications

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

Contact Info

Product

Resources

About