Microwave-assisted solvent-free synthesis of iminothiazolines

Synthesis of 1,3‐Selenazol‐2(3H)‐imines

“…Whereas the analogous synthesis of 1,3-thiazol-2(3H)-imines 9 via the reaction of thioureas 7 with phenacyl bromides 8, i.e. the Hantzsch condensation reaction [15], is well known [16][17][18][19][20][21] (Scheme 1), no synthesis of the corresponding 1,3-selenazol-2(3H)-imines has been reported so far.…”

One-Pot Synthesis of 5-Arylidene-2-Imino-4-Thiazolidinones under Microwave Irradiation

“…The 2-imino-thiazolidinones in turn were obtained by condensation of thiourea with chloroacetyl chloride in the presence of triethylamine in CHCl 3 at room temperature. We have previously reported the synthesis of iminothiazolines [11] by Hantzsch cyclisation using microwave-irradiation. In similar fashion and following the same strategy, we describe herein the one-pot three component solvent-free reaction of the thioureas 1a,a', chloroacetic acid and an appropriate aldehydes 2a-e under microwave-irradiation according to Scheme 1.…”

Synthesis and reactivity of 6‐methyl‐4H‐furo[3,2c]pyran‐3,4‐dione

“…Three different procedures (A–C) have been applied in the Hantzsch reaction. The first one (A) consider the conventional Hantzsch reaction [1, 4, 5, 31–45], by refluxing an ethanol solution of 4 with thioamides, thiourea, and diphenylthiocarbazone for 4–6 h, being the reaction products obtained in good yields and without need of purification. Microwave irradiation was used as an alternative source of heating in the other methods, using ethanol as solvent (B) or in the solvent‐free reaction conditions (C).…”