“Microwave-Assisted, Solvent Free, One Pot Synthesis of Novel Bioactive Imidazolyl - Pyrazole derivatives catalyzed by Mesolite type Natural Zeolite”

Abstract

Novel Imidazolyl-Pyrazole derivatives have been synthesized by cyclocondensation of 1, 3-diphenyl pyrazole-4-carbaldehyde, benzil, and substituted aniline and ammonium acetate by using mesolite type natural zeolite as an efficient and heterogenous catalyst under microwave condition. The synthesised novel Imidazolyl-Pyrazole derivatives are fully characterized by FT-IR, 1H-NMR, 13C-NMR and LC-MS techniques. The synthesized Imidazolyl-Pyrazole derivatives were screened for anti-bacterial and anti-fungal activities and compared with standard drug molecules.