Microwave Assisted Phase Transfer Catalysis: An Efficient Solvent‐Free Method for the Synthesis of Cyclopropane Derivatives

Gumaste, V. K.; Khan, Asgar Jafar; Bhawal, B. M.; Deshmukh, A. R. A. S.

doi:10.1002/chin.200421046

Cited by 6 publications

(6 citation statements)

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“…The solvent-free, solid-liquid phase reaction mixtures were irradiated in the presence of a phase transfer catalyst. Dialkylation of CH-acidic compounds with one equivalent of 1,2-dibromoethane under MW-PTC conditions gave the corresponding cyclopropane derivatives [11].…”

Section: Introductionmentioning

confidence: 99%

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates Under Solvent-Free Conditions

Keglevich¹,

Majrik²,

Vida³

et al. 2008

LOC

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An ecofriendly, microwave (MW) promoted and solventless method is described for the alkylation of diethyl malonate, ethyl acetoacetate and ethyl cyanoacetate by a variety of alkyl halides in the presence of K 2 CO 3 . In the solidliquid phase alkylation of active methylene containing substrates, it seems to be of general value that the phase-transfer catalyst, that is an onium salt in the present case, can be omitted and substituted by MW irradiation promoting the formation of the potassium salt of the substrate and its transfer to the organic phase. In certain cases, the use of triethylbenzylammonium chloride led to the formation of by-products under the conditions (~160 °C/~12 bar) applied.

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Section: Introductionmentioning

confidence: 99%

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates Under Solvent-Free Conditions

Keglevich¹,

Majrik²,

Vida³

et al. 2008

LOC

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“…Dialkylation of active methylene containing substrates by one equivalent of 1,2-dibromoethane under similar conditions led to cyclopropane derivatives. 6 There is, however, one main drawback regarding the environmentallyfriendly aspects of the PTC-MW technique, that is the waste of phase transfer catalysts. On an industrial scale, the amount of the catalyst used cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Microwave irradiation as an alternative to phase transfer catalysis in the liquid-solid phase, solvent-free C-alkylation of active methylene containing substrates

et al. 2006

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“…Indian scientists synthesized disubstituted cyclopropane derivatives (10) from active methylene containing compounds and 1,2-dibromoethane by a MW-assisted and phase transfer catalyzed solvent-free approach (Scheme 5) [16].…”

Section: Scheme 4 Alkylation Ethyl Phenylmercaptoacetate (8) Under Mmentioning

confidence: 99%

Solid-Liquid Phase C-Alkylation of Active Methylene Containing Compounds under Microwave Conditions

Grűn

Bálint²,

Keglevich

2015

Catalysts

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Abstract:The solid-liquid phase C-alkylation of active methylene containing compounds with C=O or P=O functions under phase transfer catalysis or microwave conditions has been summarized in this minireview. The mono-and dialkylation of the methylene containing derivatives was investigated under microwave (MW) conditions. It was found that in many cases, there was no need to use phase transfer catalyst under MW conditions. Moreover, most of the reactions were carried out without any solvent. These results mean a serious green chemical advantage.

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Microwave Assisted Phase Transfer Catalysis: An Efficient Solvent‐Free Method for the Synthesis of Cyclopropane Derivatives

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 6 publications

References 0 publications

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates Under Solvent-Free Conditions

Microwave Irradiation as a Green Alternative to Phase Transfer Catalysis: Solid-Liquid Phase Alkylation of Active Methylene Containing Substrates Under Solvent-Free Conditions

Microwave irradiation as an alternative to phase transfer catalysis in the liquid-solid phase, solvent-free C-alkylation of active methylene containing substrates

Solid-Liquid Phase C-Alkylation of Active Methylene Containing Compounds under Microwave Conditions

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