Microwave-Assisted Organic Synthesis: General Considerations and Transformations of Heterocyclic Compounds

Kranjc, Krištof; Kočevar, Marijan

doi:10.2174/138527210791130488

Cited by 79 publications

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“…In earlier syntheses, special catalysts (e.g. BiNO 3 [22], phthalocyanine [23], lanthanoid(OTf) 3 [24], magnesium perchlorate [25] and gallium(III) iodide [26]) were applied that cannot be regarded environmentally friendly species. We proved that under MW conditions there was no need for any catalyst.…”

Section: Methodsmentioning

confidence: 99%

“…The most valuable benefit is when a reaction can be performed that is impossible on conventional heat ing. This may be the consequence of a so-called special MW effect [3]. The most common benefits from MW irradiation are the considerable shortening of the reaction times and the increase in the selectivity and yield.…”

Section: The Potential Of Microwave Irradiation In Synthetic Organic mentioning

confidence: 99%

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Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Keglevich

Grűn²,

Bagi³

et al. 2015

Period. Polytech. Chem. Eng.

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The use of the microwave (MW) Keywords organophosphorus chemistry, green chemistry, microwave, resolution, platinum complexes, dronic acids/dronates IntroductionIn this minireview, our recent results in environmentallyfriendly ("green") chemistry have been summarized. In the first sub-chapter the usefulness of the microwave technique is shown in organophosphorus chemistry. The second sub-chapter summarizes our results on the resolution of cyclic phosphine oxides, as precursors for P-ligands and on the synthesis of platinum complexes as potential catalysts. Catalysts are of utmost importance from the point of view of green chemistry. The last sub-chapter comprises our experiences on the optimization of the synthesis of dronic acid derivatives that are important drugs against bone diseases.

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Section: Methodsmentioning

confidence: 99%

Section: The Potential Of Microwave Irradiation In Synthetic Organic mentioning

confidence: 99%

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Keglevich

Grűn²,

Bagi³

et al. 2015

Period. Polytech. Chem. Eng.

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“…In recent years, application of microwaves to synthetic organic chemistry has become increasingly popular and attracted considerable practical [16][17][18][19] and theoretical attention [20]. The most common benefits from microwave irradiation are the considerable shortening of reaction times, thereby accelerating reaction rates, and the increase in the selectivities.…”

Section: Application Of Microwave In the Hirao Reaction: The Benefitsmentioning

confidence: 99%

Microwave-assisted Hirao reaction: recent developments

Brahmachari

2015

ChemTexts

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Organic molecules containing phosphorus, now, constitute a major branch of chemistry, and offer fascinating possibilities for their structural, synthetic, and mechanistic study as well as promising biological activities. Organophosphorus compounds find numerous potential applications in the areas of industrial, agricultural, and medicinal chemistry. Aryl-and vinyl-phosphonates are an important class of organophosphorus compounds with potential biological relevance. The Hirao reaction offers a way to access these compounds through phosphorus-carbon (P-C) cross-coupling of aryl and vinyl halides with O,O-dialkyl phosphites, and this reaction has attained a commendable development in many ways in regard to the diversity in the substrates, [P(O)H species, catalysts, and reaction conditions. The present article deals with such developments that occurred under the influence of microwave irradiation.

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“…Considering thermal effects, local overheatings occurring statistically in the bulk of the mixture may be responsible for the beneficial effect of MWs [10].…”

Section: Introductionmentioning

confidence: 99%

<strong>The potential and scope of the microwave tool; A case study on the synthesis of phosphinates </strong>

Keglevich

Kiss

2017

Proceedings of the 21st International Electronic Conference on Synthetic Organic Chemistry

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Microwave (MW) irradiation has had a positive impact also on organophosphorus chemistry. This is demonstrated via the synthesis of phosphinates from phosphinic acids. The scope and limitations of the use of the MW technique, along with the modeling of the distribution of the beneficial effect of the local overheatings and the prediction of the acceleration is discussed. All these are possible on the basis of the energetics calculated for a selected esterification by quantum chemical methods.Keywords: phosphinic acid; phosphinate; microwave; ionic liquid; green chemistry; scope and limitation of the use of MW; modeling the effect of MW; conformation

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Microwave-Assisted Organic Synthesis: General Considerations and Transformations of Heterocyclic Compounds

Cited by 79 publications

References 0 publications

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Microwave-assisted Hirao reaction: recent developments

<strong>The potential and scope of the microwave tool; A case study on the synthesis of phosphinates </strong>

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Microwave-Assisted Organic Synthesis: General Considerations and Transformations of Heterocyclic Compounds

Cited by 79 publications

References 0 publications

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Environmentally Friendly Chemistry with Organophosphorus Syntheses in Focus

Microwave-assisted Hirao reaction: recent developments

<strong>The potential and scope of the microwave tool; A case study on the synthesis of phosphinates&nbsp;</strong>

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<strong>The potential and scope of the microwave tool; A case study on the synthesis of phosphinates </strong>