Microwave-Assisted One-Step Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles Using 1,4- Bis(triphenylphosphonium)-2-Butene Peroxodisulfate

Gholami, Maryam; Afshari, Mozhgan; Nazari, Simin

doi:10.13005/ojc/290448

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Gorjizadeh et al reported the efficient synthesis of a series of 1,3,4-oxadiazoles ( 3 ) from the cyclization–oxidation reaction of acyl hydrazones ( 1 ) with substituted aldehydes ( 2 ) by using 1,4-bis(triphenylphosphonium)-2-butene peroxodisulfate (BTPPDS) as an oxidant in a solvent-free medium under microwave irradiation ( Scheme 3 ). The reaction was found to proceed smoothly under microwave irradiation within 25 min, whereas 12 h were required to complete the reaction under reflux conditions [ 21 ].…”

Section: Chemistry Of Oxadiazolemoietymentioning

confidence: 99%

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

et al. 2021

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Green synthetic protocol refers to the development of processes for the sustainable production of chemicals and materials. For the synthesis of various biologically active compounds, energy-efficient and environmentally benign processes are applied, such as microwave irradiation technology, ultrasound-mediated synthesis, photo-catalysis (ultraviolet, visible and infrared irradiation), molecular sieving, grinding and milling techniques, etc. Thesemethods are considered sustainable technology and become valuable green protocol to synthesize new drug molecules as theyprovidenumerous benefits over conventional synthetic methods.Based on this concept, oxadiazole derivatives are synthesized under microwave irradiation technique to reduce the formation of byproduct so that the product yield can be increased quantitatively in less reaction time. Hence, the synthesis of drug molecules under microwave irradiation follows a green chemistry approach that employs a set of principles to minimize or remove the utilization and production of hazardous toxic materials during the design, manufacture and application of chemical substances.This approach plays a major role in controlling environmental pollution by utilizing safer solvents, catalysts, suitable reaction conditions and thereby increases the atom economy and energy efficiency. Oxadiazole is a five-membered heterocyclic compound that possesses one oxygen and two nitrogen atoms in the ring system.Oxadiazole moiety is drawing considerable interest for the development of new drug candidates with potential therapeutic activities including antibacterial, antifungal, antiviral, anticonvulsant, anticancer, antimalarial, antitubercular, anti-asthmatic, antidepressant, antidiabetic, antioxidant, antiparkinsonian, analgesic and antiinflammatory, etc. This review focuses on different synthetic approaches of oxadiazole derivatives under microwave heating method and study of their various biological activities.

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Section: Chemistry Of Oxadiazolemoietymentioning

confidence: 99%

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

et al. 2021

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“…Among the different organophos-phorics, trialkyl phosphates, PO(OR) 3 , that are produced in important amount, are noticeably relevant and are widely employed in different technological areas as extractors of rare and radioactive elements, inhibitors of metal corrosion and polymer burning, additives to combustible and lubricating materials, brake-liquids, etc 4-6 . Other secondary reactions are possible, know the condensation reaction which from monophosphates forms pyrophosphates (Scheme 3).…”

mentioning

confidence: 99%

Solvent-Free Microwave Synthesis of Trialkylphosphates

Meddour-Boukhobza¹,

Elias²,

Didi³

2014

Orient. J. Chem

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Eco‐friendly approaches to 1,3,4‐oxadiazole derivatives: A comprehensive review of green synthetic strategies

Shah,

Patel

2024

Archiv der Pharmazie

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This review article offers an environmentally benign synthesis of 1,3,4‐oxadiazole derivatives, with a focus on sustainable methodologies that have minimal impact on the environment. These derivatives, known for their diverse applications, have conventionally been associated with synthesis methods that utilize hazardous reagents and produce significant waste, thereby raising environmental concerns. The green synthesis of 1,3,4‐oxadiazole derivatives employs renewable substrates, nontoxic catalysts, and mild reaction conditions, aiming to minimize the environmental impact. Innovative techniques such as catalyst‐based, catalyst‐free, electrochemical synthesis, green‐solvent‐mediated synthesis, grinding, microwave‐mediated synthesis, and photosynthesis are implemented, providing benefits in terms of scalability, cost‐effectiveness, and ease of purification. This review emphasizes the significance of sustainable methodologies in the synthesis of 1,3,4‐oxadiazole and boots for continued exploration in this research domain.

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Microwave-Assisted One-Step Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles Using 1,4- Bis(triphenylphosphonium)-2-Butene Peroxodisulfate

Cited by 5 publications

References 13 publications

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

Solvent-Free Microwave Synthesis of Trialkylphosphates

Eco‐friendly approaches to 1,3,4‐oxadiazole derivatives: A comprehensive review of green synthetic strategies

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