“…Biginelli reaction is an efficient one-pot multicomponent condensation reaction that is used widely in organic and medical chemistry (Bose et al, 2005;Kulkarn et al, 2009;Mochaddas et al, 2012). Starting from aldehyde, Urea(thiourea) and β-keto ester under strongly acidic condition represented by Lewis acid to obtaine the pyrimidine-2-one analogs (Kappe, 1993;Mohammadizadeh and Firoozi, 2011), which received a significant attention owing to their biological (Shutalev et al, 1998;Mobinikhaledi and Kalhor, 2010) and pharmaceutical properties (Phucho et al, 2009;Piqani and Zhang, 2011;Shaikh et al, 2012) such as antihypertensive (Atwal et al, 1989;Atwal et al, 1990), antiinflammatory and antibacterial (Jadhav et al, 2012;Badadhe et al, 2011, Akbas et al, 2010 and antimicrobial (Beena and Akelesh, 2012) were also studied depending on this type of synthesis.…”