Microwave‐Assisted One‐Pot Synthesis of 2,3‐Disubstituted 3H‐Quinazolin‐4‐ones.

Abstract

Fused pyrimidine derivatives R 0515Microwave-Assisted One-Pot Synthesis of 2,3-Disubstituted 3H-Quinazolin--4-ones. -Reaction of anthranilic acids with carboxylic acids or acid chlorides and subsequent microwave-promoted ring closure provides an efficient one-pot synthesis of the title skeleton, present in many natural compounds. -(LIU*, J.-F.; LEE, J.; DALTON, A. M.; BI, G.; YU, L.; BALDINO, C. M.; MCELORY, E.; BROWN, M.; Tetrahedron Lett. 46 (2005) 8, 1241-1244; ArQule, Inc., Woburn, MA 01801, USA; Eng.) -Mais 23-160

Construction of Some Novel Biocidal N-Alkylated Quinazoline-4(3h)- One Derivatives Using Microwave Activation

“…A multitude of efficient procedures for the construction of quinazolinone derivatives is using classical methods of heating 20,21 . Recently, uses of microwave activation for performing chemical reactions was accomplished as a nonconventional heating source; particularly for the 4(3H)-quinazolinones 22,23 .…”