Microwave assisted one-pot green synthesis of cinnoline derivatives inside natural sporopollenin microcapsules

Abstract

We have achievedin situmicrowave assisted green syntheses of a novel cinnoline derivative inside natural sporopollenin microreactors.

Encapsulation of erythromycin and bacitracin antibiotics into natural sporopollenin microcapsules: antibacterial, cytotoxicity,in vitroandin vivorelease studies for enhanced bioavailability

“…Nevertheless, in contracts to the results of Bohne et al, 50 the LCS extracted from Lycopodium clavatum species did not show such barriers as revealed in several studies where various materials were successfully loaded inside them. [19][20][21][22]46 Following the SEM morphological and structural characterisations, which cannot solely give loading conrmation, we have used CLSM analysis to verify the encapsulation of EM or BAC within the LCS. Since these antibiotics do not have Scheme 1 Proposed mechanism of passive-vacuum antibiotic encapsulation into empty LCS microcapsules.…”

“…Due to their resilience, consistency in size and unique morphology, sporopollenin have recently attracted intriguing attention for a wide range of applications acting as either microparticles (as solid support) [10][11][12][13][14][15][16] or microcapsules (for diverse encapsulation of materials). 3,[17][18][19][20][21][22] The majority of research concerning sporopollenin has arisen from the thickshelled ($1.5 mm) S-type species of Lycopodium clavatum L. spores (common club moss or ground pine). Moreover, sporopollenin from L. clavatum have recently shown high efficiencies in encapsulation of drugs, 21,23 live cells, 20 oils, 18,24 proteins 19 and inorganic nanoparticles.…”

Microwave-assisted efficient one-pot synthesis of N2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

“…In continuation of our efforts in performing green methodologies in the synthesis of biologically relevant heterocycles from simple starting materials [41][42][43][44], we developed an efficient synthesis of N 2 -(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamines through the one-pot reaction of cyanamide 1, aromatic aldehydes 2, and 5-aminotetrazole (3) in pyridine under controlled microwave heating (Scheme 2).…”

Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-2,3-dihydro-1,3,5-triazine-2,4-diamines

“…In continuation of our efforts in performing green methodologies in the synthesis of biologically relevant heterocycles from simple starting materials [43][44][45][46], we developed an efficient synthesis of N 2 -(tetrazol-5-yl)-6-aryl/heteroaryl-…”