Microwave‐Assisted Nanocatalysed Synthesis of Phenacyl Halides as Future Anti‐Platelet Agents

Jangid, Dinesh Kumar; Dhadda, Surbhi; Goswami, Prakash; Guleria, Anjali; Pareek, Kapil; Jangir, Nidhi; Poonam,

doi:10.1002/slct.201901416

Cited by 2 publications

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References 36 publications

(27 reference statements)

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“…In 2019, Jangid and co-workers developed a TiO 2 nanoparticle (NP)-catalysed bromination and chlorination of aromatic ketones [ 75 ]. With the corresponding NXS and t -butyl hydrogen peroxide (TBHP), 12 α-haloketones were obtained in good to excellent yields ( Scheme 22 ).…”

Section: Direct α-Halogenation Of Aryl Ketonesmentioning

confidence: 99%

Synthetic Access to Aromatic α-Haloketones

et al. 2022

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α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.

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Section: Direct α-Halogenation Of Aryl Ketonesmentioning

confidence: 99%

Synthetic Access to Aromatic α-Haloketones

et al. 2022

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“…Phenacyl bromides are significant organic intermediates for the formation of heterocyclic skeleton and industrialized key intermediates, which act as valuable molecular fragment for the progress of range of bioactive compounds, [1][2][3][4] natural and non-natural products. [5] Over the years, for the bromination of acetophenones various reagents have been reported, [6] e. g. molecular bromine, [7] cupric bromide, [8] ammoniumbromide, [9] MgBr 2 -(hydroxy(tosyloxy)iodo) benzene-MW, [10] N-methylpyrrolidin-2-onehydrotribromide (MPHT), [11] (CH 3 ) 3 SiBr, [12] DMS [13] and KBr.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Catalytic Bromination of Acetophenones Using Taguchi's Method

Jangir,

Sohu,

Bagaria

et al. 2023

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A new, efficient and environmental benign one‐pot protocol for the synthesis of α‐bromoacetophenones has been designed via the regioselective monobromination of aromatic carbonyl compounds with Bromodimethylsulfonium Bromide (BDMS) in catalytic environment of MgO nanoparticles and products were obtained in moderate to superior yields. Structure of synthesized compounds were elucidated by their 1H and 13C NMR spectroscopy, further Taguchi based optimization is utilized to maximize the product yield using L27 Orthogonal Array (OA) constructed by five control factors including acetophenones (AP), BDMS, Temperature, Time and MgO with their three levels. The optimal level of AP, BDMS, Temperature, Time and MgO are found up to 1.0 mmol, 2.0 mmol, 60 °C, 50 Min and 10 mol%, respectively.

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Microwave‐Assisted Nanocatalysed Synthesis of Phenacyl Halides as Future Anti‐Platelet Agents

Cited by 2 publications

References 36 publications

Synthetic Access to Aromatic α-Haloketones

Synthetic Access to Aromatic α-Haloketones

Optimization of Catalytic Bromination of Acetophenones Using Taguchi's Method

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