Microwave-assisted extraction of active pharmaceutical ingredient from solid dosage forms

Hoang, Tung; Sharma, Rakesh; Susanto, David Febrilliant; Maso, Marie Di; Kwong, Elizabeth

doi:10.1016/j.chroma.2007.02.060

Cited by 28 publications

(11 citation statements)

References 11 publications

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“…Several methods were developed for quantitative estimation of MO such as voltametric [10], capillary electrophoresis [12], spectroflurometry [15] spectrophotometry [17], and liquid chromatography (LC) [2–9, 11, 13, 14, 16]. Some methods were developed in pharmaceutical [11–14, 16, 17] and biological fluids [2–10, 15].…”

Section: Introductionmentioning

confidence: 99%

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Method Development and Validation of Montelukast in Human Plasma by HPLC Coupled with ESI-MS/MS: Application to a Bioequivalence Study

Challa

Awen²,

Chandu³

et al. 2010

Sci. Pharm.

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A simple, sensitive, and specific LC-ESI–MS/MS method for quantification of Montelukast (MO) in human plasma using Montelukast-d6 (MOD6) as an internal standard (IS) is discussed here. Chromatographic separation was performed on YMC-pack pro C18, 50 x 4.6 mm, S-3 μm column with an isocratic mobile phase composed of 10mM ammonium formate (pH 4.0):acetonitrile (20:80 v/v), at a flow-rate of 0.8 mL min−1. MO and MOD6 were detected with proton adducts at m/z 586.2→568.2 and 592.3→574.2 in multiple reaction monitoring (MRM) positive mode respectively. MO and MOD6 were extracted using acetonitrile as precipitating agent. The method was validated over a linear concentration range of 1.0–800.0 ng mL−1 with correlation coefficient (r2) ≥ 0.9996. The intraday precision and accuracy were within 1.91–7.10 and 98.32–99.17. The inter-day precision and accuracy were within 3.42–4.41% and 98.14–99.27% for MO. Both analytes were found to be stable throughout three freeze-thawing cycles, bench top, and autosampler stability studies. This method was utilized successfully for the analysis of plasma samples following oral administration of MO (5 mg) in 31 healthy Indian male human volunteers under fasting conditions.

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Section: Introductionmentioning

confidence: 99%

“…Some methods were developed in pharmaceutical [11–14, 16, 17] and biological fluids [2–10, 15]. Moreover, voltametric [10], capillary electrophoresis [12], spectrophotometry [17], spectroflurometry [15] involves tedious procedure and too many steps which do not satisfy the determination of the samples.…”

Section: Introductionmentioning

confidence: 99%

Method Development and Validation of Montelukast in Human Plasma by HPLC Coupled with ESI-MS/MS: Application to a Bioequivalence Study

Challa

Awen²,

Chandu³

et al. 2010

Sci. Pharm.

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“…Traditionally, Berberis root extract was prepared by boiling, decoction and infusion, while, maceration and microwave assisted extraction (MAE) techniques are used during laboratory experiments 29,30 . Reports revealed that various compounds of nutraceutical and pharmaceutical interest have been extracted by MAE method 21,[31][32][33] . The MAE is reported as a green extraction method, as it provides both faster extraction and lesser or no solvent consumption 34,35 .…”

mentioning

confidence: 99%

Optimized microwave assisted extraction (MAE) of alkaloids and polyphenols from Berberis roots using multiple-component analysis

Belwal

Pandey

Bhatt

et al. 2020

Sci Rep

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Berberis, one of the major sources of berberine and polyphenols, is widely accepted genus for its medicinal properties. The inclusion of these phytochemicals in different health formulations has widened its scope in pharmaceuticals and nutraceuticals. in the present study, multi-component analysis (McA) has been used to extract these nutraceutical compounds from Berberis jaeschkeana roots under microwave-assisted extraction (MAe) conditions. to determine the optimum extraction condition, different factors, including, microwave power, sample to solvent ratio, irradiation time, solvent pH and solvent concentration were tested under 42 experiments. The MCA includes, Plackett-Burmen and Central Composite Design and analyzes model fitness, regression coefficient (β), analysis of variance (ANOVA) and 3D response curve. The results showed significant model fitness and involvement of linear, quadratic and interactive effect of different factors. Under optimized MAE condition, [i.e. 1 g of sample extracted through 70 mL of a solution (100% methanol pH 2.0), provided microwave power of 598 W for 2 min of irradiation time], the berberine and palmatine contents were recorded as 46.38 mg g −1 and 20.54 mg g −1 respectively. Under optimized condition, the yield of alkaloids were found closer to the models' predicted value. Similarly, total phenolic content and antioxidant activities were also found closer to the models' predicted value. to test the suitability of the optimized MAe condition for other species i.e., Berberis asiatica, extraction of alkaloids and polyphenolics was conducted and recorded higher yield to the previous records. Moreover, under optimum extraction condition, six and seven polyphenolic compounds from B. jaeschkeana and B. asiatica were quantified respectively. The proposed MAe optimization design using McA contributes towards faster and greener extraction of alkaloids and polyphenolics with higher yield. Moreover these greener approaches could sustainably utilize species during extract preparation and harnessing its nutraceutical and pharmaceutical potential. this study design could also be replicated on other valuable species or compounds for effective extraction of nutraceutical components and sustainable utilization of natural products.

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“…[1][2] Montelukast is a specifi c cysteinyl leukotriene receptor antagonist belonging to a styryl quinolines series with the chemical name 2-[1-[1(R)-[3-[2(E)-(7-chloroquinolin-2yl) vinyl] phenyl]-3[2-(1-hydroxy-1-methylethyl) phenyl] propylsulfanylmethyl] cyclo-propyl] acetic acid sodium salt. sodium include HPLC, [5] protein precipitation, [6] liquid chromatography/tandem mass spectrometry(LC-MS/ MS), [7] liquid-liquid extraction using HPLC with the fl uorescence detector, [8] its S-enantiomer in human plasma by stereoselective high performance liquid chromatography (HPLC) using column-switching [9] and its determination in human plasma by the column-switching HPLC method, [10] derivative spectroscopy, HPLC, [11] microwaveassisted extraction (MAE) technique, [12] method for the application of pressurized liquid extraction technology for pharmaceutical solid dosage form [13] Residual acetate analysis in bulk drug. [14] No spectrophotometric method or the HPLC method has been reported in the literature for the simultaneous determination of montelukast and rupatadine in their commercial formulations.…”

Section: Introductionmentioning

confidence: 99%

Derivative spectrophotometry method for simultaneous estimation of rupatadine and montelukast in their combined dosage form

Pg¹,

Vm²,

Sg³

et al. 2009

J Young Pharmacists

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Microwave-assisted extraction of active pharmaceutical ingredient from solid dosage forms

Cited by 28 publications

References 11 publications

Method Development and Validation of Montelukast in Human Plasma by HPLC Coupled with ESI-MS/MS: Application to a Bioequivalence Study

Method Development and Validation of Montelukast in Human Plasma by HPLC Coupled with ESI-MS/MS: Application to a Bioequivalence Study

Optimized microwave assisted extraction (MAE) of alkaloids and polyphenols from Berberis roots using multiple-component analysis

Derivative spectrophotometry method for simultaneous estimation of rupatadine and montelukast in their combined dosage form

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