Microwave-assisted deep eutectic solvent extraction of phenolic antioxidants from onion (Allium cepa L.) peel: a Box–Behnken design approach for optimization

Pal, Chandra Bhushan T; Jadeja, Girirajsinh C.

doi:10.1007/s13197-019-03891-7

Cited by 61 publications

(39 citation statements)

References 36 publications

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“…For the optimization study, a BBD experimental design was used to obtain the variable combinations for the experimental runs ( Table 2 ). This enabled the experimental runs of a smaller number of samples with reliable results, because the number of levels for the factors is minimized (from five to three in our case) [ 45 , 46 ], and it generates less extreme experimental combinations compared to a central composite design (CCD) [ 47 ]. The prediction precision around the supposed optimum is similar to the CCD, because the center point level is repeated (three times in the current study), but with fewer runs [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…The prediction precision around the supposed optimum is similar to the CCD, because the center point level is repeated (three times in the current study), but with fewer runs [ 48 ]. However, the efficiency of BBD was shown to be higher than CCD and three-level full factorial [ 28 , 45 ], providing a model with a better fit. Thus, by using the BBD, the number of experiments was significantly reduced compared to the fully factorial design with five levels as in the preliminary study.…”

Section: Resultsmentioning

confidence: 99%

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Optimization of Moist and Oven-Dried Bacterial Cellulose Production for Functional Properties

et al. 2021

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Bacterial cellulose (BC) is a natural polymer with properties suitable for tissue engineering and possible applications in scaffold production. However, current procedures have limitations in obtaining BC pellicles with the desired structural, physical, and mechanical properties. Thus, this study analyzed the optimal culture conditions of BC membranes and two types of processing: draining and oven-drying. The aim was to obtain BC membranes with properties suitable for a wound dressing material. Two studies were carried out. In the preliminary study, the medium (100 mL) was inoculated with varying volumes (1, 2, 3, 4, and 5 mL) and incubated statically for different periods (3, 6, 9, 12, and 18 days), using a full factorial experimental design. Thickness, uniformity, weight, and yield were evaluated. In the optimization study, a Box–Behnken design was used. Two independent variables were used: inoculum volume (X1: 1, 3, and 5 mL) and fermentation period (X2: 6, 12, and 18 d) to determine the target response variables: thickness, swelling ratio, drug release, fiber diameter, tensile strength, and Young’s modulus for both dry and moist BC membranes. The mathematical modelling of the effect of the two independent variables was performed by response surface methodology (RSM). The obtained models were validated with new experimental values and confirmed for all tested properties, except Young’s modulus of oven-dried BC. Thus, the optimal properties in terms of a scaffold material of the moist BC were obtained with an inoculum volume of 5% (v/v) and 16 d of fermentation. While, for the oven-dried membranes, optimal properties were obtained with a 4% (v/v) and 14 d of fermentation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Optimization of Moist and Oven-Dried Bacterial Cellulose Production for Functional Properties

et al. 2021

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“…Chi-square value (χ 2 ) measures the accuracy of models and determines the acceptability of data with the expected distribution data. It can be calculated using the formula (Bhushan and Girirajsinh 2019) in Eq. (31):where C experimental and C predicted refer to the experimental and predicted values of the concentration responses, respectively, and n refers to the sample points taken.…”

Section: Statistical Modeling and Evaluationmentioning

confidence: 99%

Techniques and modeling of polyphenol extraction from food: a review

et al. 2021

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There is a growing demand for vegetal food having health benefits such as improving the immune system. This is due in particular to the presence of polyphenols present in small amounts in many fruits, vegetables and functional foods. Extracting polyphenols is challenging because extraction techniques should not alter food quality. Here, we review technologies for extracting polyphenolic compounds from foods. Conventional techniques include percolation, decoction, heat reflux extraction, Soxhlet extraction and maceration, whereas advanced techniques are ultrasound-assisted extraction, microwave-assisted extraction, supercritical fluid extraction, high-voltage electric discharge, pulse electric field extraction and enzyme-assisted extraction. Advanced techniques are 32-36% more efficient with approximately 15 times less energy consumption and producing higher-quality extracts. Membrane separation and encapsulation appear promising to improve the sustainability of separating polyphenolic compounds. We present kinetic models and their influence on process parameters such as solvent type, solid and solvent ratio, temperature and particle size.

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“…For the optimization study a BBD experimental design was used to obtain the variable combinations for the experimental runs (Table 2). This enabled the experimental runs of a smaller number of samples with reliable results because the number of levels for the factors is minimized (from 5 to 3 in our case) (Pal and Jadeja 2019; Rodsamran and Sothornvit 2019) and it generates less extreme experimental combinations compared to Central Composite Design (CCD) (Otto 2016). The prediction precision around the supposed optimum is similar to the CCD because the center point level is repeated (3 times in the current study), but with fewer runs (Addinsoft 2020).…”

Section: Optimization Studymentioning

confidence: 99%

Optimization of moist and oven-dried bacterial cellulose production for functional properties

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Beteg

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et al. 2021

Preprint

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Bacterial cellulose (BC) is a natural polymer with properties suitable for tissue engineering and possible applications in scaffold production. However, current procedures have limitations in obtaining BC pellicles with the desired structural, physical, and mechanical properties. Thus, this study analyzed the optimal culture conditions of BC membranes and 2 types of processing: draining and oven-drying. The aim was to obtain BC membranes with properties suitable for a wound dressing material. Two studies were carried out. In the preliminary study the medium (100 mL) was inoculated with varying volumes (1; 2; 3; 4; and 5 mL) and incubated statically for different periods (3; 6; 9; 12; and 18 days), using a full factorial experimental design. Thickness, uniformity, weight, and yield were evaluated. In the optimization study, a Box–Behnken design was used. Two independent variables were used: inoculum volume (X1: 1; 3; and 5 mL) and fermentation period (X2: 6; 12; and 18 d) to determine the target response variables: thickness, swelling ratio, drug release, fiber diameter, Tensile strength, and Young's Modulus for both dry and moist BC membranes. The mathematical modelling of the effect of the 2 independent variables was accomplished by response surface methodology (RSM). The obtained models were validated with new experimental values, and confirmed for all tested properties, except Young Modulus of oven-dried BC. Thus, the optimal properties in terms of a scaffold material of the moist BC were obtained with an inoculum volume of 5% (v/v) and 16 d of fermentation. While, for the oven-dried membranes a 4% (v/v) and 14 d of fermentation.

show abstract

Microwave-assisted deep eutectic solvent extraction of phenolic antioxidants from onion (Allium cepa L.) peel: a Box–Behnken design approach for optimization

Cited by 61 publications

References 36 publications

Optimization of Moist and Oven-Dried Bacterial Cellulose Production for Functional Properties

Optimization of Moist and Oven-Dried Bacterial Cellulose Production for Functional Properties

Techniques and modeling of polyphenol extraction from food: a review

Optimization of moist and oven-dried bacterial cellulose production for functional properties

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