Microwave‐Assisted Concise Total Syntheses of Quinazolinobenzodiazepine Alkaloids.

Abstract

Alkaloids U 0600Microwave-Assisted Concise Total Syntheses of Quinazolinobenzodiazepine Alkaloids. -A number of title alkaloids such as sclerotigenin (IIIa), circumdatin F (IIIb), and asperlicin C (IIId) as well as related compounds like (VII) is prepared via novel microwave-promoted one-pot domino reactions. -(LIU*, J.-F.; KASELJ, M.; ISOME, Y.; CHAPNICK, J.; ZHANG, B.; BI, G.; YOHANNES, D.; YU, L.; BALDINO, C. M.; J.

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

“…The chemical structure of the circumdatins have been revisited, based on the crystal structures of circumdatins A and B. 21 Only the isolation, spectroscopic and crystallographic characterization, and chemical synthesis, [23][24][25] but not the biosynthetic gene clusters, have been reported on the circumdatins. Therefore, this review does not cover the pentacyclic pyrrolobenzodiazepines, but does focus on the bacterial PBDs, hereafter referred to as PBDs.…”

Green Synthetic Approaches for Medium Ring-Sized Heterocycles of Biological Interest

“…10 Balasubramide (10) Unknown [12] 11 Sclerotigenin R 1 = H (11) Circumdatin F R 1 = Me (12) Inhibitor of mammalian mitochondrial respiratory chain [13] 12 10 Balasubramide (10) Unknown [12] 11 Sclerotigenin R 1 = H (11) Circumdatin F R 1 = Me (12) Inhibitor of mammalian mitochondrial respiratory chain [13] 12…”