Microwave assisted coating of bioactive amorphous magnesium phosphate (AMP) on polyetheretherketone (PEEK)

Ren, Yufu; Sikder, Prabaha; Lin, Boren; Bhaduri, Sarit B.

doi:10.1016/j.msec.2017.12.025

Cited by 80 publications

(61 citation statements)

References 58 publications

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“…Interestingly, the present results are in well accordance with those of Tamimi et al (); which confirmed that MgPs can also exhibit comparable gene expression levels to well‐known CaPs. However, just like previous efforts (Ren et al, ), relatively low ALP expressions are also recorded in undoped and Ag‐doped NB. This can be attributed to the fast release of Mg and consumption of Ca in the biomineralization process which in turn lowers the β‐glycerophosphate (BGP) induced ALP activity (Koju et al, ; Ren et al, ).…”

Section: Discussionsupporting

confidence: 68%

“…In contrast, MC3T3 cells cultured in single‐phasic doped and undoped NB exhibited up‐regulation in late‐stage markers of osteoblast differentiation–Col1 and OCN. OCN is a late‐stage marker and influences extracellular matrix (ECM) mineralization and new bone formation (Ren, Sikder, Lin, & Bhaduri, ; Viereck et al, ). The increase of OCN expressions suggests the high biomineralization capability of the doped NB samples.…”

Section: Discussionmentioning

confidence: 99%

“…However, just like previous efforts , relatively low ALP expressions are also recorded in undoped and Ag-doped NB. This can be attributed to the fast release of Mg and consumption of Ca in the biomineralization process which in turn lowers the β-glycerophosphate (BGP) induced ALP activity Ren et al, 2018). It is worth mentioning that the doped single-phase materials like NB-1Ag, NB-1.5Ag, and NB-2Ag materials possess effective antibacterial properties and similar bone regenerative potential to well-known and well-explored CaPs.…”

Section: Discussionmentioning

confidence: 99%

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Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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This article reports for the first time our successful result in the synthesis of antibacterial single‐phase newberyite (NB, MgHPO4.3H2O), an important magnesium phosphate (MgP) bioceramic. The prime novelty lies in the fact that we explore novel MgPs as next‐generation orthopedic biomaterials as opposed to conventional calcium phosphates (CaP). While NB has already shown great promise, unlike its competitor struvite (ST, MgNH4PO4.6H2O), NB is not intrinsically antibacterial. Given the havoc created by surgical site infections (SSI) in orthopedics, it would be worthwhile to explore if antibacterial NB can be synthesized cost‐effectively. To accomplish that central goal, we used silver ion (Ag+) containing precursor solutions and exposed those to microwave irradiation. This action resulted in the rapid synthesis of NB microplatelets. Besides, three other specific objectives are addressed. First, Ag‐doping was optimized to preserve the single‐phase nature for sustained dopant release. Second, Ag+ release kinetics against common infection causing bacterial strains was analyzed. Finally, we inspected for any harmful effect of Ag‐doped NB on MC3T3 preosteoblasts. Interestingly, the single‐phase nature of NB microplatelets can be retained until 2 wt % Ag‐doping and they exhibit good antibacterial and cytocompatible properties. Even though 3 wt % Ag‐doped compositions (composites) were 100% antibacterial; they were cytotoxic.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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“…Finally, 54 articles were included in present systematic review. Detailed data of the incorporated studies are listed as: 36 invitro studies in Table and 18 invivo studies in Table on PEEK material to find its efficacy as dental implant material .…”

Section: Resultsmentioning

confidence: 99%

“…LPPK remarkably stimulated rBMSCs responses and found to be important for dental utility . Amorphous magnesium phosphate layering on PEEK surface can enhance formation of novel bone and thus promotes osseointegration …”

Section: Discussionmentioning

confidence: 99%

PEEK materials as an alternative to titanium in dental implants: A systematic review

Mishra¹,

Chowdhary

2018

Clin Implant Dent Rel Res

149

121

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Purpose Evaluation of the available research on PEEK materials to find that whether PEEK material has favorable properties and can enhance osseointegration, so that they can be utilize as implants material. Materials and Methods An electronic and structured systematic search was undertaken in May 2018, without any restrictions of time in the Medline/Pubmed, Sci‐hub, Ebscohost, Cochrane, and Web of Science databases. To identify other related references further hand search was done. Articles related to PEEK and their applications in implants were only included. Articles not available in abstract form and article other than English language were excluded. Results Initially, the search resulted in 153 papers. Independent screenings of the abstracts were done by the reviewers to identify the articles related to the question in focus. Sixty‐two studies were selected out of which 10 were further excluded due to not in English language. Two additional papers were obtained after hand searching, and finally 54 articles were included in the review. Conclusions Surface modification of PEEK seems to enhance the cell adhesion, proliferation, biocompability, and osteogenic properties of PEEK implant materials. PEEK had also influence the biofilm structure and reduces the chances of periimplant inflammations. Further research and more number of controlled clinical trials on PEEK implant is required in near future so that it can replace titanium in future.

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Design of dental implants at materials level: An overview

Jiang

Yao²,

Tang

et al. 2020

J Biomedical Materials Res

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Due to the excellent restoration of masticatory function, satisfaction on aesthetics and other superiorities, dental implants represent an effective method to resolve tooth losing and damaging. Current dental implant systems still have problems waiting to be addressed, and problems are centralized on the materials of implant bodies. This review aims to summarize major developments in the field of dental implant materials, starting with an overview on structures, procedures of dental implants and challenges of implant materials. Next, implant materials are examined in three categories, that is, metals, ceramics, and polymers, their mechanical properties, biocompatibility, and bioactivity are summarized. And as an important aspect, strategies of surface modification are also reviewed, along with some finite element analysis to guiding the research direction of implant materials. Finally, the conclusive remarks are outlined to provide an outlook on the future research directions and prospects of dental implants.

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Microwave assisted coating of bioactive amorphous magnesium phosphate (AMP) on polyetheretherketone (PEEK)

Cited by 80 publications

References 58 publications

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

PEEK materials as an alternative to titanium in dental implants: A systematic review

Design of dental implants at materials level: An overview

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