Microwave-assisted CAN-catalyzed solvent-free synthesis of N-allyl quinolone-based pyrano[4,3-b]chromene and benzopyrano[3,2-c]chromene derivatives and their antimicrobial activity

Jardosh, Hardik H.; Patel, Manish P.

doi:10.1007/s00044-012-0085-z

Cited by 30 publications

(3 citation statements)

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“…The benzopyran nucleus found in the EO constituents of A. conyzoides constitutes a molecular pattern for antiprotozoal (Narender et al 2004), antimicrobial, and antiproliferative activities of the plant (Jardosh and Patel 2013), and has antioxidant ability as well (Mladenovic et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

et al. 2019

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Canine Monocytic Ehrlichiosis (CME) is an infectious disease caused by the rickettsia organism Ehrlichia canis which is transmitted mainly the ixodid brown dog tick Rhipicephalus sanguineus . The prevalence of E. canis infection has been increasing in recent years. The World Health Organization has been warned about antibiotics resistance and one of the way to prevent this situation is found new compound with this property. Doxycycline is the treatment of choice for this tick-borne disease. Adverse effects are noted in dogs that are sensitive to this drug. Antibiotic resistance may also occur. The present study aimed to evaluate the anti- Ehrlichia properties of the essential oil of the aerial parts of Ageratum conyzoides L. in infected DH82 cells, as well as its anti- Ehrlichia activity associated with doxycycline using the checkerboard assay. A. conyzoides is a native plant from northeast Brazil with many reports of ethnopharmacological applications. The essential oil of A. conyzoides was extracted from the aerial parts of the plant using the hydrodistillation method. E. canis -infected DH82 cells were cultured in DMEM (Dulbecco’s Modified Eagle Medium), maintained at 37 °C and 5% CO 2 , and standardized at a 70% infection rate for the initiation of treatment protocols. The tests were first carried out with the aim of defining the IC 50 . The combined effect of doxycycline and A. conyzoides essential oil was then determined using the checkerboard dilution technique (checkerboard method) in which the IC 50 was 200 µg/mL. The doxycycline reduction index from the combined effect was 4.90 times resulting in a synergistic effect. To the authors’ knowledge, this is the first alternative treatment (alternative therapy) based on bioactive molecules that have antibacterial activity against E. canis .

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Section: Discussionmentioning

confidence: 99%

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

et al. 2019

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“…alkaloids [1], such as flindersine, oricine and verprisine, which are generally seen in the plant family Rutaceae [2] (figure 1). These derivatives exhibit a wide range of biological activities [3][4][5][6][7][8][9][10][11][12] such as anti-allergic, anti-bacterial, anti-microbial, anti-coagulant, anti-tumour, anti-hypertensive, anti-algal and anti-inflammatory activities. In addition to these bioactivities, some of them show cancer cell growth inhibitory activity and have been found to be potential anti-cancer agents [13].…”

Section: Introductionmentioning

confidence: 99%

An efficient synthesis of 4 H -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- n -butylammonium fluoride and their pharmacological screening

Prasad¹,

Shobhashana²,

Patel³

2017

R. Soc. open sci.

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A new series of indole-based pyranoquinoline derivatives P1–24 has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl-N-allyl-indole-3-carbaldehydes 1a–d; active methylenes 2a–c; and 4-hydroxy-1-substituted quinolin-2(1H)-one 3a–b catalysed by an organocatalyst tetra-n-butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.

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“…This has led to a serious challenge to the medical community; hence, the development of new effective antimicrobial agents is an important goal. In pursuit of this goal, our research efforts are focused on the development of novel structural moieties with promising antimicrobial properties [2,3]. Bacterial infections are still a major cause of death in the developing world.…”

Section: Introductionmentioning

confidence: 99%

An Insight into Antimicrobial Activity Substituted Benzimidazole Derivatives through QSAR Studies.

Sharma¹

2015

Drug Des

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The QSAR studies were performed on a series of benzimidazole derivatives to find out the structural requirements of their antimicrobial activities. The QSAR studies have been carried out using electronic, thermodynamic, spatial and structural descriptors along with a few structural parameters. The best QSAR (S.aureus) model having r2= 0.7886 and q2 = 0.7269 was developed by principle component regression. The results derived may be useful in further designing of more potent antimicrobial agents in series. Analysis of 2D-QSAR models provides details on the fine relationship linking structure and activity and offers clues for structural modifications that can improve the activity.

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Microwave-assisted CAN-catalyzed solvent-free synthesis of N-allyl quinolone-based pyrano[4,3-b]chromene and benzopyrano[3,2-c]chromene derivatives and their antimicrobial activity

Cited by 30 publications

References 22 publications

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

Anti-Ehrlichia properties of the essential oil of Ageratum conyzoides L. and its interaction with doxycycline

An efficient synthesis of 4 H -pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra- n -butylammonium fluoride and their pharmacological screening

An Insight into Antimicrobial Activity Substituted Benzimidazole Derivatives through QSAR Studies.

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