Microwave-activated Cu-doped zirconium metal-organic framework for a highly effective combination of microwave dynamic and thermal therapy

Feng, Yifu; Chen, Qian; Jin, Chong; Ruan, Yiwen; Chen, Qi; Lin, Weidong; Zhu, Chumeng; Zhang, Tinglin; Zhang, Yang; Gao, Jie; Mo, Jinggang

doi:10.1016/j.jconrel.2023.07.046

Cited by 10 publications

(3 citation statements)

References 67 publications

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“…To construct a synergistic therapeutic nanoplatform, we synthesized MCM following established procedures. [ 19 ] Core nanoparticles (NPs) of copper metal–organic frameworks (CM) were synthesized using a hydrothermal method. Prepared copper acetate monohydrate was mixed with 1,3,5‐Benzenetricarboxylic acid (H 3 BTC) and stirred for 12 h to obtain CM.…”

Section: Resultsmentioning

confidence: 99%

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Enhanced Bacterial Cuproptosis‐Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment

Luo,

Lu,

Shi

et al. 2024

Advanced Science

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A recently emerging cell death pathway, known as copper‐induced cell death, has demonstrated significant potential for treating infections. Existing research suggests that cells utilizing aerobic respiration, as opposed to those reliant on glycolysis, exhibit greater sensitivity to copper‐induced death. Herein, a MnO2‐loaded copper metal–organic frameworks platform is developed denoted as MCM, to enhance bacterial cuproptosis‐like death via the remodeling of bacterial respiratory metabolism. The reversal of hypoxic microenvironments induced a cascade of responses, encompassing the reactivation of suppressed immune responses and the promotion of osteogenesis and angiogenesis. Initially, MCM catalyzed O2 production, alleviating hypoxia within the biofilm and inducing a transition in bacterial respiration mode from glycolysis to aerobic respiration. Subsequently, the sensitized bacteria, characterized by enhanced tricarboxylic acid cycle activity, underwent cuproptosis‐like death owing to increased copper concentrations and aggregated intracellular dihydrolipoamide S‐acetyltransferase (DLAT). The disruption of hypoxia also stimulated suppressed dendritic cells and macrophages, thereby strengthening their antimicrobial activity through chemotaxis and phagocytosis. Moreover, the nutritional effects of copper elements, coupled with hypoxia alleviation, synergistically facilitated the regeneration of bones and blood vessels. Overall, reshaping the infection microenvironment to enhance cuproptosis‐like cell death presents a promising avenue for eradicating biofilms.

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Section: Resultsmentioning

confidence: 99%

“…MCM was constructed via hydrothermal synthesis as reported previously. [ 19 ] First, CM core nanoparticles were synthesized through a hydrothermal process. Copper acetate monohydrate was combined with H 3 BTC and stirred for 12 h, resulting in the formation of CM.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Bacterial Cuproptosis‐Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment

Luo,

Lu,

Shi

et al. 2024

Advanced Science

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“…These functions include mitigating cellular stress, exhibiting antioxidant activity, modulating immune responses, and facilitating antigen presentation. Through these functions, HSPs confer cellular resilience to various modes of cell death, including ferroptosis ( 67 ). One member of this family, heat shock protein B1 (HSPB1), also known as HSP25 or HSP27, safeguards the integrity of the actin cytoskeleton.…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Achieving Complete Tumor Clearance: A Minimalist Manganese Hydrogel for Magnetic Resonance Imaging‐Guided Synergetic Microwave Ablation and Chemodynamic Therapy

Zhou,

Shu,

Luo

et al. 2024

Adv Healthcare Materials

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The combination of microwave ablation (MWA) and chemodynamic therapy (CDT) presents a promising strategy for complete eradication of residual tumor after MWA. However, it remains challenging and urgent to develop a facile, biocompatible, and imaging‐guided platform for the achievement of this goal. Herein, we propose a minimalist manganese hydrogel (ALG‐Mn hydrogel) for synergistic MWA and CDT to completely eradicate tumor in vivo. The ALG‐Mn hydrogel is prepared using a simple mixing method and exhibited excellent syringeability, remarkable microwave sensitivity, and potent Fenton‐like activity. By assisting in MWA procedures, the ALG‐Mn hydrogel enables both elimination of primary tumor mass through enhanced MWA efficacy and eradication of potential residual tumor tissues via robust CDT. This approach achieves complete tumor clearance without requiring additional drug loading. Furthermore, the paramagnetic Mn2+ component allows real‐time dynamic visualization of the ALG‐Mn hydrogel at the tumor site via magnetic resonance imaging (MRI). To our best of knowledge, the proposed ALG‐Mn hydrogel represents the minimalist biocompatible platform for imaging‐guided synergistic MWA and CDT towards achieving complete tumor clearance.This article is protected by copyright. All rights reserved

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Microwave-activated Cu-doped zirconium metal-organic framework for a highly effective combination of microwave dynamic and thermal therapy

Cited by 10 publications

References 67 publications

Enhanced Bacterial Cuproptosis‐Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment

Enhanced Bacterial Cuproptosis‐Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Achieving Complete Tumor Clearance: A Minimalist Manganese Hydrogel for Magnetic Resonance Imaging‐Guided Synergetic Microwave Ablation and Chemodynamic Therapy

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