Microwave absorption-based magnetic liquid metal nano-missiles for thermodynamic/immunological cascade hepatoma therapy

Liu, Zonghao; Tan, Xiao; Huang, Yueru; Li, Weikun; Yang, Ning; Yuan, Renqiang; Chen, Qiang; Liu, Ling; Ge, Liqin

doi:10.1016/j.cej.2023.144688

Cited by 8 publications

(10 citation statements)

References 64 publications

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“…Fabrication and Characterization of MLM Nanoplatform. The MLM nanoplatform was synthesized via two steps based on our previous research work 30 (Figure 1a). First, Fe 3 O 4 NPs were mixed into liquid metal to prepare MLM.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The shell of ALG microgel and HA-coating could inhibit the oxidation and aggregation of MLM NPs to efficiently improve the dispersion stability. 30 Meanwhile, stable aqueous MLMAL NPs show good potential as DDS due to the swelling adsorption nature of the outer shell microgel and either noncovalent interaction (e.g., physical encapsulation and electrostatic interaction). The successful DOX loading was confirmed according to the FTIR spectra.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The MLM nanoplatform was fabricated through a simple sonication process and then LBL self-assembly technology based on our previous research work. 30…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…27−29 Meanwhile, nanohybrid-based magnetic and dielectric sensitizers are prospective MW absorbers that improve efficiency of converting MW electromagnetic energy to thermal energy. 30 However, studies involving the shape transformation of LM NPs by MW-driven processes have not been adequately investigated.…”

Section: ■ Introductionmentioning

confidence: 99%

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Transformable Magnetic Liquid-Metal Nanoplatform for Intracellular Drug Delivery and MR Imaging-Guided Microwave Thermochemotherapy

Liu,

Li,

Tan

et al. 2024

ACS Appl. Mater. Interfaces

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Improved techniques for the administration of chemotherapeutic drugs are required to enhance tumor therapy efficacy and reduce the side effects of chemotherapy due to insufficient targeting and limited intratumoral drug release. Controlled drug delivery systems combined with thermotherapy are expected to play an important role in personalized tumor therapy. Herein, a novel microwave-responsive transformable magnetic liquidmetal (MLM) nanoplatform is designed for effective endosomal escape that facilitates intracellular drug delivery and enhanced anticancer therapy. The MLM nanoplatform exhibits a sensitive magnetic resonance imaging function for imaging-guided therapy and brilliant synergistic effects of chemotherapy with microwave thermal therapy to kill tumor cells. Once endocytosed by targeted tumor cells, the deep penetration of microwave energy can be absorbed by the MLM nanoplatform to convert heat and reactive oxygen species, which induces the shape transformation from nanospheres to large rods, resulting in the physical disruption of the endosomal membrane for intracellular drug release. Furthermore, the MLM nanoplatform synergistic therapy could activate immunomodulatory effects by M1 macrophage polarization and T cell infiltration, thus inhibiting tumor growth and lung metastasis. This work based on microwave-driven transformable magnetic liquid-metal nanoplatform provides novel ways to precisely control drug delivery and high-efficiency cancer therapy.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The MLM nanoplatform was fabricated through a simple sonication process and then LBL self-assembly technology based on our previous research work. 30…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Transformable Magnetic Liquid-Metal Nanoplatform for Intracellular Drug Delivery and MR Imaging-Guided Microwave Thermochemotherapy

Liu,

Li,

Tan

et al. 2024

ACS Appl. Mater. Interfaces

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“…The natural resonance and eddy current loss of Ni nanoparticles caused magnetic loss, which shifted the MA frequency to the medical frequency band, and then the heterointerface of MNRC formed by nanoengineering further induced significant interfacial polarization to increase dielectric loss, and effectively enhance the intensity of the generated MA. In addition, MNRC with strong MA performance at the medical frequency band not only improved the MW thermal effect for MWT but also promoted the production of reactive oxygen species (ROS) at the tumor site to mediate microwave dynamic therapy (MDT), achieving MDT combined with MWT for tumor inhibition. − Moreover, as a member of the platinum group metal, Ru has a variety of valence states, such as Ru 0 , Ru 3+ , and Ru 4+ , enabling MNRC to consume glutathione (GSH) and H 2 O 2 to produce O 2 in the tumor microenvironment (TME) and regulating and improving the hypoxia and high-redox properties . Finally, this MNRC-mediated microwave thermal/dynamics therapy (MTDT) effectively inhibited the development of breast cancer in the model of 4T1 tumor-bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Yu,

Li,

Ren

et al. 2024

ACS Nano

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Microwave thermotherapy (MWT) has shown great potential in cancer treatment due to its deep tissue penetration and minimally invasive nature. However, the poor microwave absorption (MA) properties of the microwave thermal sensitizer in the medical frequency band significantly limit the thermal effect of MWT and then weaken the therapeutic efficacy. In this paper, a Ni-based multilayer heterointerface nanomissile of MOFs-Ni-Ru@COFs (MNRC) with improved MA performance in the desired frequency band via introducing magnetic loss and dielectric loss is developed for MWT-based treatment. The loading of the Ni nanoparticle in MNRC mediates the magnetic loss, introducing the MA in the medical frequency band. The heterointerface formed in the MNRC by nanoengineering induces significant interfacial polarization, increasing the dielectric loss and then enhancing the generated MA performance. Moreover, MNRC with the strong MA performance in the desired frequency range not only enhances the MW thermal effect of MWT but also facilitates the electron and energy transfer, generating reactive oxygen species (ROS) at tumor sites to mediate microwave dynamic therapy (MDT). The strategy of strengthening the MA performance of the sensitizer in the medical frequency band to improve MWT-MDT provides a direction for expanding the clinical application of MWT in tumor treatment.

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Liquid Metal Functionalization Innovations in Wearables and Soft Robotics for Smart Healthcare Applications

Chen,

Fan,

Chan

et al. 2023

Adv Funct Materials

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Smart healthcare solutions are crucial for early diagnosis, real‐time health monitoring, and personalized therapy. Essential to these advancements are flexible wearable devices and medical robotics, which incorporate a range of elements, including soft sensors, therapeutic modules, human‐machine interfaces, actuators, and systems for communication, computation, and power. Liquid metal‐based materials are rapidly emerging as one of the key elements for these innovations. This review will delve into the latest breakthroughs in liquid metal (LM) functionalization innovation and the applications in healthcare‐related wearables and soft robotics. Firstly, techniques to modify LM are explored, emphasizing strategies to enhance properties such as electromechanical, thermal, electromagnetic, biochemical, self‐healing, and magnetic capabilities. Next, the authors shed light on contemporary wearable sensors, therapeutic on‐skin devices, and other flexible device innovations. They finally conclude by highlighting the challenges and charting the path forward for LM‐driven healthcare advances.

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Microwave absorption-based magnetic liquid metal nano-missiles for thermodynamic/immunological cascade hepatoma therapy

Cited by 8 publications

References 64 publications

Transformable Magnetic Liquid-Metal Nanoplatform for Intracellular Drug Delivery and MR Imaging-Guided Microwave Thermochemotherapy

Transformable Magnetic Liquid-Metal Nanoplatform for Intracellular Drug Delivery and MR Imaging-Guided Microwave Thermochemotherapy

Magnetic Bimetallic Heterointerface Nanomissiles with Enhanced Microwave Absorption for Microwave Thermal/Dynamics Therapy of Breast Cancer

Liquid Metal Functionalization Innovations in Wearables and Soft Robotics for Smart Healthcare Applications

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