Microwave Ablation with Multiple Simultaneously Powered Small-gauge Triaxial Antennas: Results from an in Vivo Swine Liver Model

Brace, Christopher L.; Laeseke, Paul F.; Sampson, Lisa A.; Frey, Tina M.; Weide, Daniel W. van der; Lee, Fred T.

doi:10.1148/radiol.2441052054

Cited by 105 publications

(84 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, our results are difficult to generalize to clinical trials that use singleantenna systems and deliver less energy to target tissues (28,29). There are methods to quantify thermal dose response in ex-vivo tissue to account for different energy delivery approaches, but data on the relationship with blood vessels are limited (30).…”

Section: Discussionmentioning

confidence: 99%

Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma

Chiang¹,

Cristescu²,

Lee³

et al. 2016

Radiology

Self Cite

View full text Add to dashboard Cite

Purpose:To characterize vessel occlusion rates and their role in local tumor progression in patients with hepatocellular carcinoma (HCC) who underwent microwave tumor ablation. Materials and Methods:This Results:Occlusion was identified in 39.7% of portal veins (29 of 73), 15.0% of hepatic veins (six of 40), and 14.2% of hepatic arteries (10 of 70) encompassed within the ablation zone. Hepatic vein occlusion was significantly correlated with a smaller vessel size (P = .036) and vessel-antenna spacing (P = .006). Portal vein occlusion was only significantly correlated with a smaller vessel size (P = .001), particularly in vessels that were less than 3 mm in diameter. Local tumor progression rates were significantly correlated with patent hepatic arteries within the ablation zone (P = .02) but not with patent hepatic (P = .57) or portal (P = .14) veins. Conclusion:During microwave ablation of HCC, hepatic veins and arteries were resistant to vessel occlusion compared with portal veins, and only arterial patency within an ablation zone was related to local tumor progression.q RSNA, 2016

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma

Chiang¹,

Cristescu²,

Lee³

et al. 2016

Radiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…[17][18][19] Recently, multiple-electrode RFA approaches, including the switching monopolar (SM) mode, bipolar mode and multipolar mode, have been attempted with each demonstrating efficiency in creating a larger ablation zone in liver tissue than in the standard monopolar RF technique. 2,[20][21][22][23][24][25][26] Theoretically, RFA in switching bipolar (SB) mode using multiple electrodes should further improve the thermal and electronic efficiency of RFA devices compared to conventional monopolar modes. However, until now, the efficacy of SB-RFA with internally cooled wet (ICW) electrodes, which allow simultaneous internal cooling and saline infusion, in creating 3-to 5-cm coagulation areas, have not been tested in previous in vivo studies.…”

mentioning

confidence: 99%

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Yoon

Lee²,

Woo

et al. 2015

BJR

View full text Add to dashboard Cite

Objective: To evaluate whether switching bipolar radiofrequency ablation (SB-RFA) using three internally cooled wet (ICW) electrodes can induce coagulations .5 cm in porcine livers with better efficiency than consecutive monopolar (CM) or switching monopolar (SM) modes. The mean D min of coagulations was significantly larger in Group C than in Groups A and B (5.1 6 0.9, 3.9 6 1.2 and 4.4 6 1.0 cm, respectively, p 5 0.002) at a lower delivered RF energy level (76.8 6 14.3, 120.9 6 24.5 and 114.2 6 18.3 kJ, respectively, p , 0.001). Conclusion: SB-RFA using three ICW electrodes can create coagulations .5 cm in diameter with better efficiency than do SM-or CM-RFA. Advances in knowledge: SB-RFA can create large, regular ablation zones with better time-energy efficiency than do CM-or SM-RFA.

show abstract

“…Several studies used a series of microwave dose to carry out in vitro and in vivo MWA experiments. [22][23][24][25][26] Di®erent size of ablation zones were obtained in these experiments, which provided reference for clinicians. But such ablation experiments were mostly carried out in livers, the information from other organs was rare.…”

Section: Discussionmentioning

confidence: 94%

Real-Time Assessment of Microwave Ablation Efficacy by Nir Spectroscopic Technique

Zhao

Qian

Liu

et al. 2014

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

Microwave ablation (MWA) status monitoring in real time plays a key role in assessment of therapeutic e®ectiveness. As a novel real-time assessment method, near infrared spectroscopy (NIRs) was used to evaluate the ablation e±cacy. MWA experiments were carried out on in vitro porcine livers. An optical measurement system for biological tissue is developed by our lab to monitor reduced scattering coe±cient ( 0 s ) at 690 nm of the coagulation zones. It is noted that 0 s of liver tissue, which increases as the liver tissue being ablated, is clearly related with the coagulation status. 0 s of normal tissue and coagulated tissue is 3-5 and 17-19 cm À1 , respectively. Continuous changes of 0 s demonstrate that optical parameter can be used as an e±cacy evaluation factor because it essentially indicates the degree of thermal damage. Compared with temperature, optical parameter is more sensitive and accurate, which is promising for real-time therapeutic e±cacy assessment in MWA.

show abstract

Microwave Ablation with Multiple Simultaneously Powered Small-gauge Triaxial Antennas: Results from an in Vivo Swine Liver Model

Abstract: A single generator may effectively deliver microwave power to multiple antennas. Large volumes of tissue may be ablated and large vessels coagulated with multiple-antenna ablation in the same time as single-antenna ablation.

Cited by 105 publications

References 10 publications

Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma

Effects of Microwave Ablation on Arterial and Venous Vasculature after Treatment of Hepatocellular Carcinoma

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Real-Time Assessment of Microwave Ablation Efficacy by Nir Spectroscopic Technique

Contact Info

Product

Resources

About