Microwave ablation versus transarterial chemoembolization in large hepatocellular carcinoma: prospective analysis

Abdelaziz, Ashraf Omar; Nabeel, Mohamed Mahmoud; Elbaz, Tamer; Shousha, Hend Ibrahim; Hassan, Eman; Mahmoud, Sara; Rashed, N.; Ibrahim, Mukdad; Abdelmaksoud, Ahmed Hosni

doi:10.3109/00365521.2014.1003397

Cited by 44 publications

(30 citation statements)

References 31 publications

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“…Given that MWA can create a larger ablation zone, MWA alone or combined with TACE has increasingly been used in treating large HCC [76,77,78]. Abdelaziz et al [78] recently performed a study to compare the efficacy and safety of percutaneous MWA with TACE for large tumors (5-7 cm) and demonstrated better results for MWA than TACE in managing large HCC lesions.…”

Section: Local Ablative Therapymentioning

confidence: 99%

“…Abdelaziz et al [78] recently performed a study to compare the efficacy and safety of percutaneous MWA with TACE for large tumors (5-7 cm) and demonstrated better results for MWA than TACE in managing large HCC lesions. Another retrospective study [77] compared the outcomes of TACE combined with MWA (TACE-MWA) with TACE for treating unresectable large HCC (≥5.0 cm in diameter).…”

Section: Local Ablative Therapymentioning

confidence: 99%

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A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

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Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. Summary: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques. Key Message: Advances in image-guided locoregional therapies, including local ablative therapy and transarterial therapy, have led to a major breakthrough in the management of HCC. Both survival rates and cure rates of patients with HCC have improved markedly since the introduction of these techniques. Practical Implications: Radiofrequency ablation is currently considered as an alternative to surgical resection for patients with early-stage HCC. A newer technique of ablation such as microwave ablation is increasingly being used, especially for large HCC. Transarterial chemoembolization has become a standard care for asymptomatic patients with multinodular tumors in intermediate-stage disease, and transarterial radioembolization has become the method of choice in HCC cases with portal vein thrombosis. Moreover, combination treatment modalities, such as thermal-based ablation combined with transarterial chemoembolization or ¹²⁵I seed implant brachytherapy, may further broaden their clinical indications for HCC. Moreover, use of localized radiation in combination with thermal ablation has been reported to improve tumor control and long-term survival.

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Section: Local Ablative Therapymentioning

confidence: 99%

Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

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“…Contrast-enhanced ultrasound (CEUS)-guided MWA was performed by Liu F et al [40] in 107 patients with large HCCs (mean maximum diameter: 19.5 ± 8.5 mm) with a technical success rate of 98.13 %. Regarding comparative evaluation of MWA vs. transarterial chemoembolization (TACE) in large HCCs, Abdelaziz et al analyzed 64 patients with large HCCs [41]. MWA showed higher rates of complete ablation (75 %) with fewer sessions and a lower incidence of tumor recurrence (p = 0.02) with 13.7 months of survival.…”

Section: Mwa Results In Hccmentioning

confidence: 99%

Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms – Review Article

Vogl

Nour-Eldin

Hammerstingl

et al. 2017

Fortschr Röntgenstr

129

100

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ZUSAMMENFASSUNGHintergrund Der lokoregionale interventionelle onkologische Behandlungsansatz ist eine anerkannte Behandlungsoption bei Lebermalignomen, insbesondere beim hepatozellulären Karzinom (HCC) und oligonodulären Lebermetastasen. Material und Methode ABSTR AC T PurposeThe locoregional interventional oncological treatment approach is an accepted modality for liver neoplasms, especially for hepatocellular carcinoma (HCC) and oligonodular liver metastases. Materials and MethodsThe main aim of ablation therapies like microwave ablation (MWA) is to eradicate all malignant cells in a minimally invasive technique under imaging guidance while preserving the healthy tissue with a sufficient safety margin (at least 5 mm) surrounding the ablated lesion.Results Ablation therapy can be performed via a percutaneous, laparoscopic or intraoperative approach under ultrasound, MRI or CT guidance for adequate localization and monitoring of the ablation process.Conclusion Ablation is the method of choice for oligonodular HCCs ≤ 3 cm. The technical success rate varies from 88 % to This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.98 % and progression-free survival (PFS) at 3 years from 27 % to 91.7 %. The same criteria apply to the therapy of liver metastases. Key Points▪ Careful selection of patients proves to be essential for optimum results of MWA ▪ Interventionists should be familiar with all aspects of complication and rapid assessment of imaging methods in order to evaluate induced damage by thermal ablation ▪ MWA seems to have some advantages over radiofrequency ablation, like shorter ablation time, less pain, less heat sink effect; however, scientific proof is needed

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“…Sixty-four patients were divided into two groups and treated with either MWA or TACE. A higher rate of complete ablation (75%) was achieved with fewer sessions of MWA than of TACE, and MWA displayed a lower incidence of tumor recurrence, de novo lesions, or post-treatment ascites [69] . Though several initial studies have shown favorable results with cryoablation, many recent studies have raised concerns regarding serious side effects and complications associated with this technology, including cryoshock, hypothermia, cracking of the ice ball, hemorrhage, biloma, abscess, pleural effusion, and death [70,71] .…”

Section: Figure 2 Axial Computed Tomography Images Before and After Rmentioning

confidence: 94%

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

Kalra

Gupta

Chawla

et al. 2015

WJR

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Microwave ablation versus transarterial chemoembolization in large hepatocellular carcinoma: prospective analysis

Abstract: MWA showed better results than TACE in the management of large HCC lesions.

Cited by 44 publications

References 31 publications

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms – Review Article

Locoregional treatment for hepatocellular carcinoma: The best is yet to come

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