Microwave Ablation of Renal Cell Carcinoma

Krieger, Jordan R.; Lee, Fred T.; McCormick, Timothy; Ziemlewicz, Timothy J.; Hinshaw, J. Louis; Wells, Shane A.; Laeseke, P.; Stratchko, Lindsay; Alexander, Marci; Hedican, Sean P.; Best, Sara L.; Borza, Tudor; Nakada, Stephen Y.; Abel, E. Jason

doi:10.1089/end.2020.1078

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…When using microwave ablation, it is important to avoid direct puncture of the collecting system to avoid creating a persistent track between the urothelium and the retroperitoneum resulting in urine leak/urinoma. 30…”

Section: Microwave Ablationmentioning

confidence: 99%

“…For upper pole renal lesions that have the potential to move excessively with breathing, one available option to aid in minimizing breathing motion is to use high frequency jet ventilation. 30,35 High frequency jet ventilation can only be done under general anaesthesia. Jet ventilation is a technique where smaller title volumes are given more frequently therefore limiting large diaphragmatic excursion and renal motion.…”

Section: Sedationmentioning

confidence: 99%

“…The large thermal volumes of microwave ablation also risk injury to adjacent organs and the renal collecting system. When using microwave ablation, it is important to avoid direct puncture of the collecting system to avoid creating a persistent track between the urothelium and the retroperitoneum resulting in urine leak/urinoma 30 …”

Section: Microwave Ablationmentioning

confidence: 99%

“…Microwave ablation tends to cause more pain and may therefore more likely require anaesthesia. For upper pole renal lesions that have the potential to move excessively with breathing, one available option to aid in minimizing breathing motion is to use high frequency jet ventilation 30,35 . High frequency jet ventilation can only be done under general anaesthesia.…”

Section: Sedationmentioning

confidence: 99%

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Percutaneous treatment of renal tumours

2023

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SummaryImage‐guided ablation is an accepted treatment option in the management of renal cell carcinoma. Percutaneous renal ablation offers the possibility of minimally invasive treatment while attempting to preserve renal function. Over the past several years there have been advances in tools and techniques that have improved procedure safety and patient outcomes. This article provides an updated comprehensive review of percutaneous ablation in the management of renal cell carcinoma.

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Section: Microwave Ablationmentioning

confidence: 99%

Section: Sedationmentioning

confidence: 99%

Section: Microwave Ablationmentioning

confidence: 99%

Section: Sedationmentioning

confidence: 99%

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Percutaneous treatment of renal tumours

2023

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Enhanced abscopal anti-tumor response via a triple combination of thermal ablation, IL-21, and PD-1 inhibition therapy

Wu,

Jiang,

Fang

et al. 2024

Cancer Immunol Immunother

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Despite the success of immune checkpoint inhibitors (ICIs) in treating solid tumors, lots of patients remain unresponsive to this therapy. Microwave ablation (MWA) stimulates systemic adaptive immunity against tumor cells by releasing tumor antigens. Additionally, IL-21 has demonstrated importance in stimulating T-cell effector function. The combination of these three therapies—MWA, IL-21, and anti-PD-1 monoclonal antibodies (mAbs)—has yet to be explored in the context of cancer treatment.In this study, we explored the impact of thermal ablation on IL-21R expression in tumor-infiltrating lymphocytes (TILs). Subsequently, we assessed alterations in the tumor microenvironment (TME) and peripheral lymphoid organs. Additionally, we conducted a thorough examination of tumor-infiltrating CD45+ immune cells across various treatment groups using single-cell RNA sequencing (scRNA-seq). Moreover, we determined the potential anti-tumor effects of the triple combination involving MWA, IL-21, and anti-PD-1 mAbs.Our findings revealed that MWA upregulated the expression of IL-21R on various immune cells in the untreated tumors. The combination of MWA with IL-21 exhibited a robust abscopal anti-tumor effect, enhancing the effector function of CD8+ T cells and facilitating dendritic cells' maturation and antigen presentation in the untreated tumor. Notably, the observed abscopal anti-tumor effect resulting from the combination is contingent upon T-cell recirculation, indicating the reliance of systemic adaptive immunity for this treatment regimen. Additionally, the combination of MWA, IL-21, and PD-1 mAbs demonstrated profound abscopal anti-tumor efficacy. Our findings provide support for further clinical investigation into a triple combination therapy involving MWA, IL-21, and ICIs for the treatment of metastatic cancer.

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