Microwave ablation of hepatic malignant tumors using 1.5T MRI guidance and monitoring: feasibility and preliminary clinical experience

Lin, Zhong‐Zhe; Chen, Jin; Yuan, Yan; Chen, Jian; Li, Yuliang

doi:10.1080/02656736.2019.1690166

Cited by 17 publications

(12 citation statements)

References 20 publications

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“…Worth noting, although CT can meet the treatment requirements of MWA and provide accurate imaging, the differentiation between vital tumor tissue and the ablation zone is only possible for a limited time after application of a contrast agent. Recently, MR-guided MWA has been commonly used as a minimally invasive therapy for the treatment of liver malignancies, which can clearly obtain the boundary between the burn range and normal tissue without the use of contrast agents [19,23,24,25].…”

Section: Discussionmentioning

confidence: 99%

Image-Guided Microwave Ablation of Hepatocellular Carcinoma (≤5.0 cm): Is MR Guidance More Effective Than CT Guidance?

Wang

et al. 2021

Preprint

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BackgroundPercutaneous tumor ablation is usually performed using computed tomography (CT) or ultrasound (US) guidance, although reliable visualization of the target tumor may be challenging. MRI guidance can provide more reliable visualization of the target tumor and allow for multiplanar capabilities, making it the modality of choice. Due to the lack of comparative studies of microwave ablation(MWA) guided by different images. This study retrospectively compared the effectiveness of computed tomography (CT)-guided versus magnetic resonance (MR)-guided MWA for hepatocellular carcinoma (HCC≤5.0 cm). MethodsIn this retrospective study, 47 patients and 54 patients received MWA under the guidance of CT and MR, respectively. The inclusion criteria were a single HCC≤5.0 cm or a maximum of three. The local tumor progression (LTP), overall survival (OS), prognostic factors for local progression, and safety of this technique were assessed.ResultsAll procedures were technically successful. The complication rates of the two groups were significantly different with respect to liver abscess and pleural effusion (P<0.05). The mean LTP was 44.264 months in the CT-guided group versus 47.745 months in the MR-guided group of HCC (P = 0.629, log-rank test). The mean OS was 56.772 months in the patients who underwent the CBCT-guided procedure versus 58.123 months in those who underwent the MR-guided procedure (P = 0.630, log-rank test). Multivariate Cox regression analysis further illustrated that tumor diameter (<3 cm) and the number of lesions (single) were important factors affecting LTP and OS.ConclusionsCT-guided and MR-guided MWA are safe and effective in the treatment of HCC with a diameter of less than 5 cm. Furthermore, MR-guided MWA could reduce the incidence of complications.

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Section: Discussionmentioning

confidence: 99%

Image-Guided Microwave Ablation of Hepatocellular Carcinoma (≤5.0 cm): Is MR Guidance More Effective Than CT Guidance?

Wang

et al. 2021

Preprint

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“…Recently, MR-guided ablation has been gradually applied to the minimally invasive treatment of primary and metastatic renal malignancies [17,18]. The MR-guided method could ensure precise insertion of the applicator into the target tissue and enable monitoring and controlling the degree of tissue coagulation, to confirm that the tumor has been completely destroyed as well as reduce the impact on normal renal tissue and thermal damage to adjacent structures [19][20][21][22]. The characteristic of coagulative necrosis during MR-guided ablation is that the signal intensity on T2WI decreases while the signal intensity on T1WI increases.…”

Section: Discussionmentioning

confidence: 99%

MR-Guided Microwave Ablation in T1 Renal Cell Carcinoma: Initial Results in Clinical Routine

Jiao

Wang

et al. 2021

BioMed Research International

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Objective. Percutaneous tumor ablation is usually performed using computed tomography (CT) or ultrasound (US) guidance, although reliable visualization of the target tumor could be challenging. Magnetic resonance- (MR-) guided ablation provides more reliable visualization of the target tumors and allows multiplanar imaging of the treatment process, making it the modality of choice, in particular if lesions are small. Methods. From March 2016 to January 2018, 32 patients scheduled for percutaneous treatment of T1 RCC underwent MR-guided MWA. Complications were classified according to the Clavien grade. Kaplan–Meier survival estimates were calculated to evaluate progression-free survival (PFS). Results. Technical success was achieved in all lesions. The mean energy and procedure duration were 61.6 ± 8.7 kJ and 118.2 ± 26.7 min, respectively. The glomerular filtration rate (GFR) dropped rapidly after 1 month of treatment and slowly recovered within three months ( P < 0.05 ). Postoperative pain and fever were the most common adverse events after treatment. Perirenal hematoma, thermal injury of the psoas muscle, and abdominal distension were common complications after MWA, and the incidence rates were 9.4% (3/32), 6.3% (2/32), and 6.3% (2/32), respectively. According to the Clavien grade classification, serious complications include hydrothorax, bowel injury, and renal failure, all of which have a probability of 3.1%. Of note, the three serious complications occurred in one patient. The 1-, 2-, and 3-year PFS rates were 96.9%, 93.8%, and 83.9%, respectively. The mean PFS rates were 33.972 months (95% CI: 33.045, 35.900). Conclusion. Microwave ablation is feasible under MR guidance and provides effective treatment of RCC in one session.

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“…1.0T open low-eld magnets [15][16][17][18][19][20][21] (Table 5). Theoretically, soft tissue resolution is higher in eld strengths >1.…”

Section: Discussionmentioning

confidence: 99%

2450 MHz Microwave Ablation for Liver Metastases Under 3.0T Wide-bore Magnetic Resonance Guidance: a Pilot Study

Liu

et al. 2021

Preprint

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Purpose: To investigate the feasibility and effectiveness of 3.0T wide-bore magnetic resonance (MR)-guided microwave ablation (MA) for liver metastases (LM).Patients and methods: From October 2018 to May 2020, 39 patients with 63 LM were treated with 3.0T wide-bore MR-guided 2450 MHz MA therapy. The procedure parameters, technical success, complications, biochemical indexes changes, local tumor response, local tumor progression (LTP) and overall survival were recorded and analyzed.Results: The mean tumor maximum diameter and total procedure time were 3.0 cm and 55.2 min, respectively. Technical success was 100% but 5 cases (12.8%) with grade-1 complications. Alanine transaminase, aspartate transaminase and total bilirubin showed slight a transient increase on day 3 (P<0.05) and returned to normal by day 30 (P>0.05). The complete ablation rate for ≦ 2.5 and >2.5 cm lesions were 100 % and 92.5 %, respectively, during the median followup of 12.0 months, LTP rate was 4.8 % (3/63), and the 6-, 12- and 18-month overall survival were 100%, 92.2%, 76.4% , respectively.Conclusion: 3.0T wide-bore MR-guided MA for LM is a safe and effective approach, especially for small LM.

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Microwave ablation of hepatic malignant tumors using 1.5T MRI guidance and monitoring: feasibility and preliminary clinical experience

Cited by 17 publications

References 20 publications

Image-Guided Microwave Ablation of Hepatocellular Carcinoma (≤5.0 cm): Is MR Guidance More Effective Than CT Guidance?

Image-Guided Microwave Ablation of Hepatocellular Carcinoma (≤5.0 cm): Is MR Guidance More Effective Than CT Guidance?

MR-Guided Microwave Ablation in T1 Renal Cell Carcinoma: Initial Results in Clinical Routine

2450 MHz Microwave Ablation for Liver Metastases Under 3.0T Wide-bore Magnetic Resonance Guidance: a Pilot Study

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