Microwave Ablation Antenna for Functional Adenomas in the Adrenal Gland

Farina, Laura; Marco, A. J. de; Bottiglieri, Anna; Ruvio, Giuseppe; Eaton-Evans, Jimmy; Dennedy, Michael Conall; Elahi, Muhammad Adnan; O’Halloran, Martin

doi:10.1109/piers-spring46901.2019.9017498

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…In the used applicator, back-heating along the antenna axis is limited only by the active cooling that balances the temperature increase. Thus, such increase in the longitudinal direction would be expected, but could be easily minimized adopting a different antenna design [33,34].…”

Section: Discussionmentioning

confidence: 99%

Exploiting Tissue Dielectric Properties to Shape Microwave Thermal Ablation Zones

Bottiglieri

Ruvio

O’Halloran

et al. 2020

Sensors

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The dielectric characterization of tissue targets of microwave thermal ablation (MTA) have improved the efficacy and pre-procedural planning of treatment. In some clinical scenarios, the tissue target lies at the interface with an external layer of fat. The aim of this work is to investigate the influence of the dielectric contrast between fat and target tissue on the shape and size of the ablation zone. A 2.45 GHz monopole antenna is placed parallel to an interface modelled by fat and a tissue characterized by higher dielectric properties and powered at 30 and 60 W for 60 s. The performances of MTA are numerically investigated considering different interface scenarios (i.e., different widths of fat layer, shifts in the antenna alignment) and a homogeneous reference scenario. Experiments (N = 10) are conducted on ex vivo porcine tissue to validate the numerical results. Asymmetric heating patterns are obtained in the interface scenario, the ablation zone in the target tissue is two-fold to ten-fold the size of the zone in the adipose tissue, and up to four times larger than the homogenous scenario. The adipose tissue reflects the electromagnetic energy into the adjacent tissue target, reducing the heating in the opposite direction.

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Section: Discussionmentioning

confidence: 99%

Exploiting Tissue Dielectric Properties to Shape Microwave Thermal Ablation Zones

Bottiglieri

Ruvio

O’Halloran

et al. 2020

Sensors

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“…Thus, the anemia status of both groups was significantly improved after treatment. However, the relationship between vitamin D and anemia has not been elucidated, indicating the need for further investigations in this area [23,24]. Uremic secondary hyperparathyroidism usually affects multiple organs in patients, and PTH has a significant negative impact on cardiac function in patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism

Zhu¹,

Li²,

Chen³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the effect of microwave ablation of parathyroid glands in combination with active vitamin D on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. Methods: One hundred and twenty maintenance-hemodialysis patients with uremic secondary hyperparathyroidism admitted to Meizhou People’s Hospital were assigned to 2 groups (A and B) in the order of their admission. Each group had 60 patients. Both groups were treated with active vitamin D, while patients in group A were, in addition, subjected to microwave ablation of parathyroid glands. Blood pressure, and indices for cardiac function, thyroid function s and anemia were determined. Results: After treatment, the blood pressure of group A was significantly lower than that of group B (p < 0.05). Moreover, after treatment, there were significant improvements in indices of cardiac function, thyroid function and anemia in group A patients, relative to group B patients. Conclusion: Microwave ablation of parathyroid glands, when combined with active vitamin D, improves blood pressure, cardiac function and anemia status. Furthermore, the combined therapy enhances recovery of thyroid function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism. However, the combined therapy should be subjected to further clinical trials prior to application in clinical practice. Keywords: Microwave ablation; Parathyroid glands; Active vitamin D; Hyperparathyroidism

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“…The triaxial monopole applicator was placed parallel to the interface between the fat and the adrenal cortex. The antenna was operated at 30 W and 60 W for 60 s. The applicator was designed as described in [ 16 ]. The overall diameter of the applicator is 2 mm.…”

Section: Methodsmentioning

confidence: 99%

MWA Performed at 5.8 GHz through ‘Side Firing’ Approach: An Exploratory Study

Bottiglieri

Brace

O’Halloran

et al. 2022

Sensors

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Recent studies have shown that ablation techniques have the potential to eradicate adrenal adenomas while preserving the functionalities of the adrenal gland and the surrounding anatomical structures. This study explores a new microwave ablation (MWA) approach operating at 5.8 GHz and using anatomical and dielectric characteristics of the target tissue to create directional heating patterns. Numerical simulations are executed in planar and 3D adrenal models, considering two energy doses. The numerical study is refined accounting for the vaporization of the tissue water content. Ex vivo experimental evaluations on porcine adrenal models complete the study. The numerical and experimental results show that spherical ablation zones are able to cover the target for both energy doses considered. Nonetheless, most of the non-targeted tissues can be preserved from excessive heating when low energy level is used. Numerical models accounting for water vaporization are capable to foresee the experimental temperature values. This study shows that the proposed MWA directional approach operating at 5.8 GHz can be considered for creating effective and selective ablation zones.

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Microwave Ablation Antenna for Functional Adenomas in the Adrenal Gland

Cited by 5 publications

References 20 publications

Exploiting Tissue Dielectric Properties to Shape Microwave Thermal Ablation Zones

Exploiting Tissue Dielectric Properties to Shape Microwave Thermal Ablation Zones

Effect of combined vitamin D and microwave ablation of parathyroid glands on blood pressure and cardiac function in maintenance-hemodialysis patients with uremic secondary hyperparathyroidism

MWA Performed at 5.8 GHz through ‘Side Firing’ Approach: An Exploratory Study

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