Microvessel Density Evaluation of the Effect of Enamel Matrix Derivative on Soft Tissue After Implant Placement: A Preliminary Study

Guimarães, George Furtado; Araújo, Vera Cavalcanti de; Nery, James Carlos; Peruzzo, Daiane Cristina; Soares, Andresa Borges

doi:10.11607/prd.2044

Cited by 10 publications

(11 citation statements)

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“…The search retrieved eleven papers on the use of EMD in the presence of dental implants in humans ( Table 3 ) [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. The studies reported the results both on soft and hard tissues.…”

Section: Resultsmentioning

confidence: 99%

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

et al. 2021

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Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy.

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Section: Resultsmentioning

confidence: 99%

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

et al. 2021

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“…Researchers consider high microvessel density beneficial for healing (26,27). The present study proposed that local inflammation following tissue damage can easily lead to vascularization.…”

Section: Discussionmentioning

confidence: 99%

“…Microvessel density among the three different methods was demonstrated to be in the order of: Direct suture> EASApprox ® skin-stretching >Kirschner wires. Researchers consider high microvessel density beneficial for healing ( 26 , 27 ). The present study proposed that local inflammation following tissue damage can easily lead to vascularization.…”

Section: Discussionmentioning

confidence: 99%

EASApprox® skin-stretching system: A secure and effective method to achieve wound closure

Song

Zhang

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Large skin defects are commonly observed in the clinic and have attracted much attention recently. Therefore, finding an effective solution for large skin defects is a global problem. The objective of the present study was to assess the effectiveness of the EASApprox® skin-stretching system for closing large skin defects. Skin defects (5×5 cm) were created on the forearms of 9 Bama miniature pigs, which were randomly divided into the following three groups: Direct suture, the new EASApprox® skin-stretching device and Kirschner wires. Microcirculation was assessed before surgery and after wound closure. Following the different treatments, the defects were sutured, and wound healing was assessed based on a clinical score. Furthermore, microscopic and ultramicroscopic structures were evaluated, including collagen, elastic fibers and the microvessel density. Significant differences in the clinical score and microvessel density were observed among the groups. Additionally, the mean length obtained for elastic fibers was larger than that obtained for the other two groups. Finally, the new EASApprox® skin-stretching device resulted in successful wound management and with only minor side effects on skin histology and microcirculation. Therefore, this method has the potential to be used for healing large skin defects.

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“…Emdogain ® (Straumann, Switzerland) is a commercial product containing a mixture of EMDs that promote periodontal tissue regeneration in the application at the root surface and have osteopromotive properties [ 58 , 59 ]. Furthermore, Emdogain ® enhances wound healing in the gingival tissue with reduced complications, such as inflammatory reaction and pain, even in skin wound healing [ 60 , 61 ]. In vitro and in vivo studies have shown that EMD reduces the secretion of chemokines and pro-inflammatory cytokines related to chemotaxis, angiogenesis, inflammation, and fibroplasia, and its effect is critical in early wound healing according to a clinical study [ 61 ].…”

Section: Therapeutics For Periodontal Wound Healingmentioning

confidence: 99%

Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

et al. 2021

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Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. The aim of this review article is to provide an overview of periodontal wound healing and discuss various surgical and pharmaceutical approaches to achieve stable wound healing and improve the treatment outcomes. In addition, detrimental and limiting factors that induce a compromised prognosis are discussed, along with the perspective and future direction for successful periodontal tissue regeneration.

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Microvessel Density Evaluation of the Effect of Enamel Matrix Derivative on Soft Tissue After Implant Placement: A Preliminary Study

Cited by 10 publications

References 0 publications

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review

EASApprox® skin-stretching system: A secure and effective method to achieve wound closure

Periodontal Wound Healing and Tissue Regeneration: A Narrative Review

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