Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

Guetz, G. Des; Uzzan, Bernard; Nicolas, Patrick; Cucherat, Michel; Morère, Jean‐François; Breau, J. L.; Perret, G

doi:10.1200/jco.2005.23.16_suppl.9641

Cited by 99 publications

(139 citation statements)

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“…Numerous lines of evidence have shown that angiogenesis, as quantitated according to MVD, which can reflect the status of angiogenesis in tumor tissue, plays a significant clinicopathologic role in cancer patients (34,35). In CRC, MVD is an important, highly significant and accurate prognostic factor (36,37). The MVD method, i.e., counting microvessels in hot spots, has been the preferred method (25).…”

Section: Discussionmentioning

confidence: 99%

“…Angiogenesis is a complex multistage process and is regulated by the balance between many stimulatory and inhibitory factors. In CRC, studies have shown that some proangiogenic factors, such as VEGFA, MMP2 and FGF2, play important roles in angiogenesis (37)(38)(39). In breast cancer, gastric cancer and hepatocellular carcinoma, STAT3 signaling controls VEGFA expression (4,5,14).…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

Qian

Guan

Gao

et al. 2011

Braz J Med Biol Res

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

Qian

Guan

Gao

et al. 2011

Braz J Med Biol Res

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“…During transcription, it undergoes alternative splicing, yielding multiple mature glycoprotein isoforms with different amino-acid lengths (VEGF-A165, -A121, -A189 and -A206) that are capable of inducing proliferation and migration of endothelial cells (ECs) (Ferrara and Bunting, 1996). Expression of VEGF-A has been found to be upregulated and suggested to be associated with progression of certain types of human tumours such as lung (Han et al, 2001), eosophageal (Kleespies et al, 2005) and colorectal cancers (Des Guetz et al, 2006). Studies on human breast cancer reported a significant relationship between high expression of VEGF-A and tumours with higher proliferation rate, negative oestrogen receptor status (Fuckar et al, 2006) and poor prognosis (Linderholm et al, 1999).…”

mentioning

confidence: 99%

Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis

et al. 2007

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Vascular endothelial cell growth factors (VEGF)-A, -C and -D have potent angio and lymphangiogenic functions in experimental models, although their role in the progression of human breast cancer is unclear. The aims of the current study were to examine the relationship between the expression of the aforementioned growth factors with the angio and lymphangiogenic characteristics of breast cancer, and to assess their suitability as potential prognostic factors. Paraffin-embedded sections of 177 primary invasive breast cancer, with complete clinical follow-up information for 10 years, were stained for VEGF-A, -C, -D, podoplanin and CD34 using standard immunohistochemical approaches. The expression of the growth factors was correlated with clinicopathological criteria and patients' survival. Lymph vessel density (LVD) and microvessel density (MVD) were assessed and correlated with expression of the growth factors. Vascular endothelial cell growth factor-A, -C and -D were highly expressed in 40, 37 and 42% of specimens, respectively. High expression of VEGF-A and -C, but not of -D, was associated with a higher LVD (P ¼ 0.013 and P ¼ 0.014, respectively), a higher MVD (Po0.001 and P ¼ 0.002, respectively), the presence of lymph node metastasis (Po0.001 and Po0.001, respectively), distant metastasis (P ¼ 0.010 and P ¼ 0.008, respectively) and a shorter Overall Survival (P ¼ 0.029 and 0.028, respectively). In conclusion, breast cancers that express high levels of VEGF-A and -C are characterised by a poor prognosis, likely through the induction of angio and lymphangiogenesis. Examination of expression of VEGF-A and -C in breast cancer may be beneficial in the identification of a subset of tumours that have a higher probability of recurrence and metastatic spread.

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“…Vascular endothelial growth factor (VEGF) also known as vascular permeability factor (VPF), induces angiogenesis and strongly increases microvascular permeability to plasma proteins. As vascular growth factors are released, proteases are also induced to degrade perivascular tissue, allowing the endothelial cells to proliferate and form primitive, immature, and, therefore, leaky vessels (Dor et al, 2001;Guetz et al, 2006). Figure 1 summarizes the main phases of tumor vasculature development.…”

Section: Dce-mri Basismentioning

confidence: 99%

Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer

Fusco¹,

Sansone²,

Petrillo³

et al. 2011

Rectal Cancer - A Multidisciplinary Approach to Management

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Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

Cited by 99 publications

References 0 publications

Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma

Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis

Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer

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