Microvessel and Lymphatic Vessel Density and VEGFR-3 Expression of Papillary Thyroid Carcinoma with Comparative Analysis of Clinicopathological Characteristics

Abstract

Background : This study was done to see if there were correlations between anatomic and molecular parameters such as microvessel density (MVD), lymphatic vessel density (LVD), and vascular endothelial growth factor receptor (VEGFR)-3 expression and various clinical parameters for papillary thyroid carcinomas of size > 1.0 cm (PTCs) and size ≤ 1.0 cm (papillary thyroid microcarcinomas, PTMCs). PTMCs were divided into two subgroups (0-5 mm and 6-10 mm). Methods : We analyzed 197 thyroid carcinomas including 113 PTCs and 84 PTMCs. Tissue samples form 30 patients from each group matched for clinical characteristics were selected for immunostaining. Results : Although PTCs and PTMCs showed significant differences in clinical characteristics, they did not show significant difference in MVD, LVD, or VEGFR-3 expression. There was a significantly higher LVD in the PTMC subgroup with the larger tumors but no difference in clinical characteristics. LVD was higher in patients > 45 years old (more apparent in the PTC group) and LVD had suggestive correlations with multicentricity and extrathyroidal extension depending on analytic conditions. Conclusions : Since LVD showed variable correlations with clinical variables for papillary carcinoma of the thyroid depending on analytic conditions, the individually planned treatments based on overall clinicopathological factors are advised.

Freeze-dried bovine amniotic membrane as a cell delivery scaffold in a porcine model of radiation-induced chronic wounds

“…Areas with the highest concentration of microvessels (vascular hot spots) were selected in each biopsy specimen. In each selected area, five high-magnification fields ( × 400) were evaluated and the average of all counted microvessels (mean microvessel density) was calculated [ 17 ].…”

Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers

“…In the selected areas, the number of blood vessels was counted in 4 different ×400 magnification fields. The results were expressed as the average number of vessels per visual field [ 12 , 13 ].…”

The diagnostic and prognostic value of vascularization in papillary thyroid microcarcinomas

“…По данным некоторых авторов, плотность микрососудов в папиллярных раках ЩЖ ассоциируется с более агрессивным инвазивным ростом [8], более частым метастазированием в лимфатические узлы шеи, повы-шенным риском рецидивирования и меньшим сроком выживания пациентов [4,8]. В результате нашего исследования не обнаружена корреляция между высоким уровнем васкуляризации ПМЩЖ и такими неблагоприятными факторами, как поздняя стадия заболевания, метастазирование и экстраорганная инвазия.…”

“…Неоангиогенез сопровождает прогрессию и метастазирование опухолей различной локализации [6]. В научной литературе есть немногочисленные противоречивые сведения о прогностическом значении ангиогенеза для ПМЩЖ [4].…”