Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor

Du, Tao; Ju, Guanqun; Zhou, Jun; Liu, Zhong; Lü, Rong; Chen, Wenxia; Zhang, Xiaoli; Zhou, Ru; Ding, Degang; Ji, Tongyu

doi:10.1007/s13577-021-00525-z

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…MSCs offer a treatment for peritoneal fibrosis; serum-free culture conditions enhanced the antifibrotic abilities of MSCs by suppressing inflammation, and their administration may be a potential therapy for preventing peritoneal fibrotic progression [140]. In addition, in kidneys, MSCs have been shown to promote M2 macrophage polarization and attenuate renal fibrosis via transferring HGF in rats [141].…”

Section: Mscs As Treatment For Organ Fibrosismentioning

confidence: 99%

The Role of MSC in Wound Healing, Scarring and Regeneration

Guillamat-Prats

2021

Cells

196

123

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Tissue repair and regeneration after damage is not completely understood, and current therapies to support this process are limited. The wound healing process is associated with cell migration and proliferation, extracellular matrix remodeling, angiogenesis and re-epithelialization. In normal conditions, a wound will lead to healing, resulting in reparation of the tissue. Several risk factors, chronic inflammation, and some diseases lead to a deficient wound closure, producing a scar that can finish with a pathological fibrosis. Mesenchymal stem/stromal cells (MSCs) are widely used for their regenerative capacity and their possible therapeutically potential. Derived products of MSCs, such as exosomes or extravesicles, have shown a therapeutic potential similar to MSCs, and these cell-free products may be interesting in clinics. MSCs or their derivative products have shown paracrine beneficial effects, regulating inflammation, modifying the fibroblast activation and production of collagen and promoting neovascularization and re-epithelialization. This review describes the effects of MSCs and their derived products in each step of the wound repair process. As well, it reviews the pre-clinical and clinical use of MSCs to benefit in skin wound healing in diabetic associated wounds and in pathophysiological fibrosis.

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Section: Mscs As Treatment For Organ Fibrosismentioning

confidence: 99%

The Role of MSC in Wound Healing, Scarring and Regeneration

Guillamat-Prats

2021

Cells

196

123

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“…However, recent proteomic studies showed that microvesicles are enriched in the endoplasmic reticulum, proteasome, and mitochondrial proteins [ 36 ]. Similar to exosomes, microvesicles expose tetraspanins CD9 and CD63 on their surface [ 49 ]. The functions and therapeutic potential of MSC-derived microvesicles have been thoroughly analyzed [ 50 , 51 , 52 ].…”

Section: Msc-derived Extracellular Vesicles: Exosomes Microvesicles A...mentioning

confidence: 99%

Apoptotic MSCs and MSC-Derived Apoptotic Bodies as New Therapeutic Tools

Холоденко

Yarygin

et al. 2022

CIMB

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Over the past two decades, mesenchymal stem cells (MSCs) have shown promising therapeutic effects both in preclinical studies (in animal models of a wide range of diseases) and in clinical trials. However, the efficacy of MSC-based therapy is not always predictable. Moreover, despite the large number of studies, the mechanisms underlying the regenerative potential of MSCs are not fully elucidated. Recently, it has been reliably established that transplanted MSCs can undergo rapid apoptosis and clearance from the recipient’s body, still exhibiting therapeutic effects, especially those associated with their immunosuppressive/immunomodulating properties. The mechanisms underlying these effects can be mediated by the efferocytosis of apoptotic MSCs by host phagocytic cells. In this concise review, we briefly describe three types of MSC-generated extracellular vesicles, through which their therapeutic functions can potentially be carried out; we focused on reviewing recent data on apoptotic MSCs and MSC-derived apoptotic bodies (MSC-ApoBDs), their functions, and the mechanisms of their therapeutic effects.

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“…MSC research has focused on MSC-derived exosomes (MSC-Exos). MSC-Exos have similar biological functions to MSCs, but are smaller in size, can penetrate biofilms, have low immunogenicity, and can be stored[ 32 , 33 ]. Microvesicles, also known as ectosomes, are heterogeneous membrane-bound vesicles with a diameter of 50-1000 nm that play an important role in cell-cell communication, tissue homeostasis, cell differentiation, and organ development and remodeling.…”

Section: Mechanism Of Action Of Mscs For Iddmentioning

confidence: 99%

Barriers to mesenchymal stromal cells for low back pain

Peng¹,

Yan²

2022

World J Stem Cells

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Intervertebral disc degeneration is the main cause of low back pain. In the past 20 years, the injection of mesenchymal stromal cells (MSCs) into the nucleus pulposus of the degenerative disc has become the main approach for the treatment of low back pain. Despite the progress made in this field, there are still many barriers to overcome. First, intervertebral disc is a highly complex load-bearing composite tissue composed of annulus fibrosus, nucleus pulposus and cartilaginous endplates. Any structural damage will change its overall biomechanical function, thereby causing progressive degeneration of the entire intervertebral disc. Therefore, MSC-based treatment strategies should not only target the degenerated nucleus pulposus but also include degenerated annulus fibrosus or cartilaginous endplates. Second, to date, there has been relatively little research on the basic biology of annulus fibrosus and cartilaginous endplates, although their pathological changes such as annular tears or fissures, Modic changes, or Schmorl's nodes are more commonly associated with low back pain. Given the high complexity of the structure and composition of the annulus fibrosus and cartilaginous endplates, it remains an open question whether any regeneration techniques are available to achieve their restorative regeneration. Finally, due to the harsh microenvironment of the degenerated intervertebral disc, the delivered MSCs die quickly. Taken together, current MSC-based regenerative medicine therapies to regenerate the entire disc complex by targeting the degenerated nucleus pulposus alone are unlikely to be successful.

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Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor

Cited by 12 publications

References 19 publications

The Role of MSC in Wound Healing, Scarring and Regeneration

The Role of MSC in Wound Healing, Scarring and Regeneration

Apoptotic MSCs and MSC-Derived Apoptotic Bodies as New Therapeutic Tools

Barriers to mesenchymal stromal cells for low back pain

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