Microvasculature of Mature Bovine Follicles and Its Changes with Ovulation.

Yamada, Osamu; Abe, Mitsuo; Takehana, Kazushige; Iwasa, Kenji; Hiraga, Takeo; Hiratsuka, Takahiro

doi:10.1262/jrd.40.307

Cited by 23 publications

(18 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with reports on other species of animal [1][2][3]12]. Additionally, scanning electron microscopy studies of ovarian follicle corrosion casts of various animals revealed similar observations [5,[13][14][15][16][17]. Thus, these findings support the concept that follicular atresia is accompanied by significant thecal capillary structural changes [18].…”

Section: Discussionsupporting

confidence: 91%

Changes in the Thecal Vasculature During Follicular Atresia in the Ovary of Swamp Buffalo

Feranil

Isobe

Nakao

2004

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. This study aimed to describe the changes in the thecal vasculature during ovarian follicular atresia in the swamp buffalo. Ovaries of Philippine swamp buffalo (Bubalus bubalis; SB), crossbred (SB × Murrah buffalo; CB) and Holstein-Friesian cow (Bos taurus; HF) were collected from slaughterhouses, fixed in 10% formalin in PBS and embedded in paraffin. Sections of healthy follicle and various follicular stages of atresia were stained with Bandeiraea simplicifolia-I lectin (BSL-I) to visualize the endothelial cells of blood vessels. In the theca interna, healthy follicles in SB had a significantly lower number of capillary vessels than other breeds and other atretic stages of follicle. From healthy to early atretic follicle, theca interna in all breeds showed a significant decrease in the area of capillary vessel. Capillary vessel area significantly increased (but was smaller than in healthy follicle) in the middle stage of atresia and declined again in the late atretic follicle (greater than in early atresia but smaller than in healthy follicle) in SB only. No significant change in the capillary vessel area of theca interna was noted in both CB and HF from early to late atretic follicles. There was no significant difference in the capillary vessel number and area of theca externa among the different breeds and atretic stages of follicle. These results suggest that there are dynamic changes occurring in the thecal vasculature of SB but not CB during follicular atresia which differs among cattle.

show abstract

Section: Discussionsupporting

confidence: 91%

Changes in the Thecal Vasculature During Follicular Atresia in the Ovary of Swamp Buffalo

Feranil

Isobe

Nakao

2004

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…The preantral follicles have the thecal layer surrounding them (Iijima et al 2006). It has been reported in rabbits (Kanzaki et al 1982, Kitai et al 1985, Kikuta et al 1991, Macchiarelli et al 1993, cows (Yamada et al 1994), and pigs (Jiang et al , 2004) that the single-layered capillary wreath in preantral follicles develops into a multilayered structure in the thickened theca interna layer as the follicles develop into larger and preovulatory follicles. Thus, VEGF gene fragment injection may contribute to the growth of preantral follicles by developing the thecal layer including the blood vessels to supply the nutrients.…”

Section: Discussionmentioning

confidence: 98%

Effect of direct ovarian injection of vascular endothelial growth factor gene fragments on follicular development in immature female rats

Shimizu¹,

Izutsu²,

Miyabayashi³

et al. 2007

Reproduction

View full text Add to dashboard Cite

Vascular endothelial growth factor (VEGF) expression in granulosa cells is associated with the thecal vasculature growth during ovarian follicular development. We hypothesized that injection of VEGF gene fragments directly into the rat ovary would induce production of a large number of ovulatory follicles and that these follicles would ovulate. To test this hypothesis, we treated immature female rats with combinations of hormones and VEGF gene fragments. The animals were divided into two groups: one group received solution containing transfection reagents as a control (nZ5), while the other group received direct ovarian injection of VEGF gene fragments at 19 (nZ5), 21 (nZ5), 23 (nZ5), or 25 (nZ5) days after birth followed by i.p. administration of 20 IU equine chorionic gonadotropin (eCG) at the age of 26 days. Forty-eight hours after eCG injection, animals were given 20 IU human chorionic gonadotropin (hCG) i.p. and then the oocytes in both groups were counted. The maximum number of ovulated oocytes was obtained when the VEGF gene fragments were injected into the rat ovary at 21 days after birth. Histological examination revealed that the injection of VEGF gene fragments markedly increased the vascular density around the preovulatory follicles and also the number of these follicles. Our data provide the first reported evidence that most ovulatory follicles generated by injection of VEGF gene fragments are able to ovulate upon hCG treatment. These results demonstrate that injection of VEGF gene fragments directly into the ovary stimulates the development of antral follicles by inducing the formation of thecal vasculature in immature female rats.

show abstract

“…The first follicular wave post-partum development and ovulation (Yamada et al 1994, Jiang et al 2003. In addition, a recent report suggested that the angioprotein-tie system that acts on angiogenesis in concert with vascular endothelial growth factor controls the blood vessels to maintain active angiogenesis in developing bovine follicles (Hayashi et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Relationship between metabolic hormones and ovulation of dominant follicle during the first follicular wave post-partum in high-producing dairy cows

Kawashima¹,

Fukihara²,

Maeda³

et al. 2007

Reproduction

View full text Add to dashboard Cite

Recent studies suggest that IGF-I is a crucial regulatory factor in follicular growth during early post-partum period. The aim of the present study was to determine in detail the changing profiles of metabolic and reproductive hormones in relation to ovulation of the dominant follicle (DF) of the first follicular wave post-partum in high-producing dairy cows. Plasma concentrations of related hormones in 22 multiparous Holstein cows were measured from 4 weeks pre-partum to 3 weeks post-partum, and the development of DF was observed with colour Doppler ultrasound. Thirteen cows showed ovulation by 15.2 days post-partum. Anovulatory cows showed higher GH and lower IGF-I levels than those in ovulatory cows during the peri-partum period. Each DF developed similarly, and a clear blood flow in the follicle wall was observed despite ovulation or anovulation. In addition, detailed endocrine profiles were analyzed in 9 out of the 22 cows. Five cows showed an increase in plasma oestradiol-17b (E2) with follicular growth followed by E2 peak, LH surge and ovulation. In these cows, plasma IGF-I concentrations remained high until 10 days post-partum followed by a gradual decrease. Subsequently, the insulin level increased together with the E2 peak towards ovulation. These profiles were not observed in anovulatory cows. In conclusion, our data strongly support the concept that IGF-I and insulin represent 'metabolic signals' of the resumption of ovarian function post-partum in high-producing dairy cows. Moreover, we provide the first visual evidence that both ovulatory and anovulatory DFs of the first follicular wave post-partum are similarly supplied with active blood flow.

show abstract

Microvasculature of Mature Bovine Follicles and Its Changes with Ovulation.

Cited by 23 publications

References 15 publications

Changes in the Thecal Vasculature During Follicular Atresia in the Ovary of Swamp Buffalo

Changes in the Thecal Vasculature During Follicular Atresia in the Ovary of Swamp Buffalo

Effect of direct ovarian injection of vascular endothelial growth factor gene fragments on follicular development in immature female rats

Relationship between metabolic hormones and ovulation of dominant follicle during the first follicular wave post-partum in high-producing dairy cows

Contact Info

Product

Resources

About