Microvasculature Dropout and Development of Normal Tension Glaucoma in Glaucoma Suspects: The Normal Tension Glaucoma Suspect Cohort Study

Jung, Younhea; Shin, Heejong; Oh, Si Eun; Kim, Seong-Ah; Lee, Ji-Young; Shin, Dong‐Hee; Jeon, Soo Ji; Kim, Yongchan; Shin, Hoon−Kyu; Choi, Jung Sik; Lee, Na Young; Park, Chan Kee

doi:10.1016/j.ajo.2022.07.020

Cited by 6 publications

(13 citation statements)

References 39 publications

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“… 35 , 36 Many population-based studies have proven that lower ocular perfusion pressure was a risk factor for the occurrence and progression of glaucoma. 37 – 39 Jung et al 40 found that NTG suspects with baseline microvasculature dropout (MvD), which indicated ocular vascular insufficiency, had a higher risk of converting to NTG. The choroidal MvD was also found in CON; however, the features and associated characteristics of MvD in CON were different from those in GON, which reflected the possibly diverse pathogenesis of peripapillary microvascular impairment.…”

Section: Discussionmentioning

confidence: 99%

Discriminating Between Compressive Optic Neuropathy With Glaucoma-Like Cupping and Glaucomatous Optic Neuropathy Using OCT and OCTA

Lei

Tang

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose To discriminate between compressive optic neuropathy with glaucoma-like cupping (GL-CON) and glaucomatous optic neuropathy (GON) by comparing the peripapillary retinal nerve fiber layer (pRNFL) thickness and retinal microvasculature using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods In this retrospective cross-sectional study, OCT scans were performed on 28 eyes of GL-CON, 34 eyes of GON, and 41control eyes to determine the pRNFL thickness, ganglion cell complex thickness, and cup/disc ratio. OCTA scans were conducted for 12 eyes of GL-CON, 15 eyes of GON, and 15 control eyes to measure the vessel density of the peripapillary and macular areas. Analysis of covariance was used to perform the comparisons, and the area under the curve was calculated. Results The GON eyes had a significantly thinner pRNFL in the inferior quadrant and greater vertical cup/disc ratio than the GL-CON eyes. In the radial peripapillary capillary segment, the vessel density of the GON in the inferior sectors was significantly lower than in the GL-CON. The superficial macular vessel density in the whole-image, peritemporal, perinasal, and peri-inferior sectors was significantly smaller in the GON group than in the GL-CON group. The best parameter for discriminating between GL-CON and GON was the superficial macular vessel density in the peritemporal sector. Conclusions GL-CON eyes showed a characteristic pattern of pRNFL and retinal microvascular changes. Translational Relevance GL-CON can be effectively distinguished from GON by detecting the alterations in the pRNFL and retinal microvasculature using OCT and OCTA.

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Section: Discussionmentioning

confidence: 99%

Discriminating Between Compressive Optic Neuropathy With Glaucoma-Like Cupping and Glaucomatous Optic Neuropathy Using OCT and OCTA

Lei

Tang

et al. 2023

Trans. Vis. Sci. Tech.

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“…A multicenter prospective cohort study was conducted to explore the role of vessel parameters in identifying individuals at risk of developing normal tension glaucoma (NTG) among NTG suspects. Patients with suspected normal tension glaucoma, exhibiting either baseline microvasculature dropout (MvD) or reduced laminar deep vessel density (VD) on OCT-A, demonstrated an increased risk of conversion [58]. Identifying such high-risk patients could enable early treatment and closer monitoring.…”

Section: Optical Coherence Tomography Angiography (Oct-a)mentioning

confidence: 99%

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Lommatzsch,

van Oterendorp

2024

JCM

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Being the primary site of degeneration, the optic nerve has always been the focus of structural glaucoma assessment. The technical advancements, mainly of optical coherence tomography (OCT), now allow for a very precise quantification of the optic nerve head and peripapillary retina morphology. By far the most commonly used structural optic nerve parameter is the thickness of the parapapillary retinal nerve fiber, which has great clinical utility but also suffers from significant limitations, mainly in advanced glaucoma. Emerging novel imaging technologies, such as OCT angiography, polarization-sensitive or visible-light OCT and adaptive optics, offer new biomarkers that have the potential to significantly improve structural glaucoma diagnostics. Another great potential lies in the processing of the data already available. Artificial intelligence does not only help increase the reliability of current biomarkers but can also integrate data from various imaging modalities and other clinical measures to increase diagnostic accuracy. And it can, in a more efficient way, draw information from available datasets, such as an OCT scan, compared to the current concept of biomarkers, which only use a fraction of the whole dataset.

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“…Проведя обследование методом ОКТА и наблюдение в динамике в течение пяти лет за пациентами с подозрением на ГНД, Jung и соавт. установили, что развитие данного заболевания чаще отмечалось у пациентов с бóльшим выпадением капилляров на уровне решетчатой мембраны склеры и в глубоком сосудистом сплетении макулы [36].…”

Section: исследование глазного кровотока при глаукоме нормального дав...unclassified

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Literature Review. Part 2. Role of Vascular Dysregulation in the Pathogenesis. Treatment of Normal Tension Glaucoma

Kurysheva,

Kim,

Plieva

et al. 2023

Oftalʹmologiâ

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Insufficient blood supply, vascular dysregulation, perfusion pressure and endothelial dysfunction may account for the pathogenic mechanism. OCT angiography (OCTA) measurements have been reported to be useful for glaucoma diagnostics. OCTA microvasculature could serve as a potential biomarker for glaucoma diagnosis. One of the important criteria for the treatment of NTG is the reduction of IOP, which is achieved by both conservative methods of treatment and laser and surgical interventions. With timely diagnosis, control of IOP and monitoring of morphofunctional changes in the eyes with NTG, it becomes possible to suspend the development of glaucoma optic neuropathy and preserve the patient’s vision for a long time.

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Microvasculature Dropout and Development of Normal Tension Glaucoma in Glaucoma Suspects: The Normal Tension Glaucoma Suspect Cohort Study

Cited by 6 publications

References 39 publications

Discriminating Between Compressive Optic Neuropathy With Glaucoma-Like Cupping and Glaucomatous Optic Neuropathy Using OCT and OCTA

Discriminating Between Compressive Optic Neuropathy With Glaucoma-Like Cupping and Glaucomatous Optic Neuropathy Using OCT and OCTA

Current Status and Future Perspectives of Optic Nerve Imaging in Glaucoma

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Literature Review. Part 2. Role of Vascular Dysregulation in the Pathogenesis. Treatment of Normal Tension Glaucoma

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